Document 2NrMNZ3EvkzE9rrQaL3ZKLpjp

AR226-2747 WL Copies to: E. I. du Pont, de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT NO. 129-68 Material Tested: Ammonium Perfluorononanoate Material Submitted by: Plastics Department Fluorocarbons Division H. kell No.: 5490 Other Code 0 ACUTE ORAL TEST Procedure: The test material was administered, as a solution in water, by intragastric intubation to young adult ChR-CD male rats in single doses. Survivors were sacrificed 14-19 days later. Results: Solution % 15 10 10 15 10 10 2 2 2 1 1 1 0.1 0.1 0.1 0,1 0.02 0.02 0.02 0.02 Dose "/kg 2250 1500 1000 670 450 300 187 130 90 60 40 26 17 12 7.7 5.1 3.4 2.3 1.5 1.0 Mortalitv* D - l d. D l d. D - 3 d. D - 1 d. D - 1 d. D - 6 d. D - 5 d. S - 19 d. S - 14 d. S - 14 d. S - 14 d. S - 14 d. S - 14 d. S - 14 d. S - 14 d. S 14 d. S - 14 d. s - 14 d. s - 14 d. s 14 d. Toxic Signs Lethal Doses: polyuria, bellycrawling, pallor, salivation, halfclosed eyes, incoordination, ruffled fur, diarrhea, continuous weight loss, emaciation Nonlethal Doses: pallor, salivation, polyuria, chewing-motions, on day of dosing at 26 mg/kg and above; weight loss for 15, 12, and 9 days at 130, 90, and 60 mg/kg, respectively; slight initial weight losses at 40 and 26 mg/kg; no clinical signs observed below 26 mg/kg Controls Weight When Killed Bodv Liver 228 184 185 143 178 177 277 365 321 316 295 334 308 331 323 348 352-377 0 t1O h-* 00 12.10 10.48 13.50 13.90 15.21 13.91 23.73 2b. 90 25.07 19.53 20.78 17.42 14.00 15.40 14.70 15.30 15 .89 * D - ( ) d. Found dead ( ) days after dosing; S - ( ) d. Sacrificed < ) days after dosing. L.W./B.W, X ICO ALP 187 mg/kg 5.70 7.30 9.92 8.54 7.86 8.57 7.37 7.81 6.18 7.04 5.21 4.54 4.65 4.55 4.40 4.29-5.11 containTSCACBl 2- STu-m-m~ar~yr.:..A.m.m.o.n.i..um perfluoronanoate moderately toxic for the male rat when administered n r n ,, ^. ! ^..!. ^slmmaattee.LLeett.1!',a'l1 JDDOoSsee <(AML?D)') bbf__*_"_ ^ 8 H n g ? k g=>._ -B--a--s--e--d----on- clinical signs, cutehev.cuouim|ipuouuiiund a papppeeaar srs t otoa cact tasasa an gaasst tr ro-' 6S' intestinal irrit-ant*- andJ "to pro"d1uce *heavy 'li*vers. ThIeP hhiigohhep sq tt* ""nnno--oefffea rcft1"1 llaewvoell forv utuh;is~ incre__a_s_e_di ili_v_e_r w_ei.ch,t. and. increased li\ >r/body weight ratio is 3.4 mg/kg of body weight. Report by: y. ~>UJp ft Elizabeth N. Miles Oral Toxicology Section ilienry Sherman Chief, Oral Toxicology Section ENM:HS/jch Date: June 13. 196ft ifced. Dos not contain t s c a c b i Compaq San