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405 UM - DuPont-5990 TRADE SECRET Study Title H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 5 of 5 Laboratoiy Project I: DuPont-5990 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) AUTHOR: Susan A. MacKenzie, V.M.D., Ph.D., D.A.B.T. Study Completed on: January 18,2002 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratoiy for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Page 1197 o f 1408 Company Sanitized. Does not contain TSCA C81 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX MM INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - F, ADULTS - 1198 Company Sanitized. Does not contain TSCA C8I ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS rp; 1 - 1 - 0 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER THYROID GLAND PROSTA1 649992 649993 649994 649995 649996 649997 649998 649999 650000 650001 650002 650003 650004 650005 650006 650007 650008 387.5 426.2 392.8 379.7 429.0 410.8 375.9 395.4 425.3 360.7 416.7 429.9 355.5 414.0 333.2 399.4 398.8 19.443 21.379 20.086 18.994 21.143 20.511 16.639 20.191 22.632 14.765 18.552 21.369 16.419 19.441 16.053 18.333 18.878 0.008 0.023 0.006 0.020 0.018 0.012 0.018 0.011 0.017 0.015 0.030 0.013 0.008 0.009 0.006 0.016 0.010 0.570 0.677 0.377 0.416 0.424 0.455 0.445 0.391 0.623 0.456 0.491 0.423 0.553 0.504 0.448 0.456 0.376 Company Sanitized. Does not contain TSCA CBI - 1199- ORGAN WEIGHTS - Fi ADULTS DuPont-5990 SEMINAL VESICLES 1.039 1.148 0.889 1.099 1.239 1.338 1.193 1.365 1.167 1.404 1.421 1.512 0.866 1.714 1.073 0.802 1.104 TESTES 3.539 3.071 3.324 2.927 3.065 3.366 3.014 2.964 3.137 3.198 3.216 3.183 3.133 3.098 2.994 3.215 2.771 EPIDIDYMIDES 0.771 0.762 0.712 0.699 0.776 0.794 0.753 0.748 0.766 0.773 0.814 0.820 0.830 0.834 0.638 0.692 0.721 BRAIN 1.996 1.957 1.974 1.830 2.064 2.030 1.906 1.954 2.034 1.760 2.031 2.072 1.968 1.982 1.821 1.980 1.979 ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: III-l - 25 mg/kg/day ANIMAL NUMBER 650009 650010 650011 650012 650013 650014 650015 650016 650017 650018 650019 FINAL BODY 368.8 380.2 422.0 444.2 390.5 376.7 351.8 437.9 375.0 376.6 385.5 LIVER 18.190 18.510 19.560 24.644 18.085 16.978 15.560 20.369 17.619 15.023 16.681 THYROID GLAND 0.020 0.012 0.012 0.016 0.016 0.006 0.027 0.017 0.015 0.012 0.018 PROSTATE 0.484 0.560 0.391 0.540 0.553 0.369 0.447 0.359 0.710 0.444 0.601 SEMINAL VESICLES 0.940 1.030 1.316 1.040 1.264 1.157 0.820 0.988 1.231 1.176 1.323 TESTES 3.056 3.448 3.385 3.294 2.787 3.098 3.181 3.206 3.181 3.046 3.288 EPIDIDYMIDES 0.728 0.765 0.742 0.749 0.718 0.680 0.778 0.724 0.721 0.862 0.748 ) DuPont-5990 BRAIN 2.028 2.094 2.043 1.998 1.888 1.930 1.902 1.949 2.040 1.904 1.994 Company Sanitized. Does not contain TSCA CBI - 1200- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (prams) FROM MALE RATS GROUP: V-l - 100 mg/kg/day ANIMAL NUMBER 650020 650022 650023 650024 650025 650026 650027 650028 650029 650030 FINAL BODY 340.1 386.3 369.2 442.8 358.0 401.0 333.9 393.9 391.9 387.8 LIVER 16.039 17.817 15.925 18.703 16.225 19.085 14.545 19.216 20.122 17.774 THYROID GLAND 0.007 0.021 0.013 0.022 0.019 0.010 0.007 0.019 0.014 0.010 PROSTATE 0.376 0.374 0.408 0.325 0.411 0.281 0.403 0.360 0.511 0.606 SEMINAL VESICLES 0.862 0.851 1.101 1.055 0.780 0.928 1.196 1.207 1.680 1.534 TESTES 3.463 2.837 3.201 3.248 3.007 3.487 2.964 3.696 3.504 2.867 EPIDIDYMIDES 0.560 0.727 0.756 0.823 0.683 0.841 0.634 0.857 0.820 0.831 ) DuPont-5990 BRAIN 2.048 1.961 2.014 2.066 1.919 2.004 1.882 1.980 2.114 2.076 Company Sanitized. Does not contain TSCA CBI - 1201 - )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS rP: 1 - 1 - 0 mg/kg/day ANIMAL NUMBER LIVER THYROID GLAND PROSTATE SEMINAL VESICLES 649992 649993 649994 649995 649996 649997 649998 649999 650000 650001 650002 650003 650004 650005 650006 650007 650008 5.018 5.016 5.114 5.002 4.928 4.993 4.426 5.106 5.321 4.093 4.452 4.971 4.619 4.696 4.818 4.590 4.734 0.002 0.005 0.002 0.005 0.004 0.003 0.005 0.003 0.004 0.004 0.007 0.003 0.002 0.002 0.002 0.004 0.003 0.147 0.159 0.096 0.110 0.099 0.111 0.118 0.099 0.146 0.126 0.118 0.098 0.156 0.122 0.134 0.114 0.094 0.268 0.269 0.226 0.289 0.289 0.326 0.317 0.345 0.274 0.389 0.341 0.352 0.244 0.414 0.322 0.201 0.277 Company Sanitized. Does not contain TSCA CBI - 1202 - ORGAN WEIGHTS - Fi ADULTS ) DuPont-5990 TESTES 0.913 0.721 0.846 0.771 0.714 0.819 0.802 0.750 0.738 0.887 0.772 0.740 0.881 0.748 0.899 0.805 0.695 EPIDIDYMIDES 0.199 0.179 0.181 0.184 0.181 0.193 0.200 0.189 0.180 0.214 0.195 0.191 0.233 0.201 0.191 0.173 0.181 BRAIN 0.515 0.459 0.503 0.482 0.481 0.494 0.507 0.494 0.478 0.488 0.487 0.482 0.554 0.479 0.547 0.496 0.496 ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP: III-l - 25 mg/kg/day ANIMAL NUMBER 650009 650010 650011 650012 650013 650014 650015 650016 650017 650018 650019 LIVER 4.932 4.868 4.635 5.548 4.631 4.507 4.423 4.652 4.698 3.989 4.327 THYROID GLAND 0.005 0.003 0.003 0.004 0.004 0.002 0.008 0.004 0.004 0.003 0.005 PROSTATE 0.131 0.147 0.093 0.122 0.142 0.098 0.127 0.082 0.189 0.118 0.156 SEMINAL VESICLES 0.255 0.271 0.312 0.234 0.324 0.307 0.233 0.226 0.328 0.312 0.343 TESTES 0.829 0.907 0.802 0.742 0.714 0.822 0.904 0.732 0.848 0.809 0.853 EPIDIDYMIDES 0.197 0.201 0.176 0.169 0.184 0.181 0.221 0.165 0.192 0.229 0.194 BRAIN 0.550 0.551 0.484 0.450 0.483 0.512 0.541 0.445 0.544 0.506 0.517 ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI - 1203 - )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP: V-l - 100 mg/kg/day ANIMAL NUMBER 650020 650022 650023 650024 650025 650026 650027 650028 650029 650030 LIVER 4.716 4.612 4.313 4.224 4.532 4.759 4.356 4.878 5.134 4.583 THYROID GLAND 0.002 0.005 0.004 0.005 0.005 0.002 0.002 0.005 0.004 0.003 PROSTATE 0.111 0.097 0.111 0.073 0.115 0.070 0.121 0.091 0.130 0.156 SEMINAL VESICLES 0.253 0.220 0.298 0.238 0.218 0.231 0.358 0.306 0.429 0.396 TESTES 1.018 0.734 0.867 0.734 0.840 0.870 0.888 0.938 0.894 0.739 EPIDIDYMIDES 0.165 0.188 0.205 0.186 0.191 0.210 0.190 0.218 0.209 0.214 BRAIN 0.602 0.508 0.546 0.467 0.536 0.500 0.564 0.503 0.539 0.535 ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI - 1204 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP: 1-1 - 0 mg/kg/day ANIMAL NUMBER LIVER THYROID GLAND PROSTATE SEMINAL VESICLES TESTES EPIDIDYMIDES 649992 649993 649994 649995 649996 649997 649998 649999 650000 650001 650002 650003 650004 650005 650006 650007 650008 9.741 10.924 10.175 10.379 10.244 10.104 8.730 10.333 11.127 8.389 9.134 10.313 8.343 9.809 8.815 9.259 9.539 0.004 0.012 0.003 0.011 0.009 0.006 0.009 0.006 0.008 0.009 0.015 0.006 0.004 0.005 0.003 0.008 0.005 0.286 0.346 0.191 0.227 0.205 0.224 0.233 0.200 0.306 0.259 0.242 0.204 0.281 0.254 0.246 0.230 0.190 0.521 0.587 0.450 0.601 0.600 0.659 0.626 0.699 0.574 0.798 0.700 0.730 0.440 0.865 0.589 0.405 0.558 1.773 1.569 1.684 1.599 1.485 1.658 1.581 1.517 1.542 1.817 1.583 1.536 1.592 1.563 1.644 1.624 1.400 0.386 0.389 0.361 0.382 0.376 0.391 0.395 0.383 0.377 0.439 0.401 0.396 0.422 0.421 0.350 0.349 0.364 DuPont-5990 Company Sanitized. Does not contain TSCA O CD )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weiqht ratio) FROM MALE RATS GROUP: III-1 - 25 mg/kg/day ANIMAL NUMBER 650009 650010 650011 650012 650013 650014 650015 650016 650017 650018 650019 LIVER 8.969 8.840 9.574 12.334 9.579 8.797 8.181 10.451 8.637 7.890 8.366 THYROID GLAND 0.010 0.006 0.006 0.008 0.008 0.003 0.014 0.009 0.007 0.006 0.009 PROSTATE 0.239 0.267 0.191 0.270 0.293 0.191 0.235 0.184 0.348 0.233 0.301 SEMINAL VESICLES 0.464 0.492 0.644 0.521 0.669 0.599 0.431 0.507 0.603 0.618 0.663 TESTES 1.507 1.647 1.657 1.649 1.476 1.605 1.672 1.645 1.559 1.600 1.649 EPIDIDYMIDES 0.359 0.365 0.363 0.375 0.380 0.352 0.409 0.371 0.353 0.453 0.375 ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI - 1206 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS rp: v- 1 - 100 mg/kg/day ANIMAL NUMBER 650020 650022 650023 650024 650025 650026 650027 650028 650029 650030 LIVER 7.832 9.086 7.907 9.053 8.455 9.523 7.728 9.705 9.518 8.562 THYROID GLAND 0.003 0.011 0.006 0.011 0.010 0.005 0.004 0.010 0.007 0.005 PROSTATE 0.184 0.191 0.203 0.157 0.214 0.140 0.214 0.182 0.242 0.292 SEMINAL VESICLES 0.421 0.434 0.547 0.511 0.406 0.463 0.635 0.610 0.795 0.739 TESTES 1.691 1.447 1.589 1.572 1.567 1.740 1.575 1.867 1.658 1.381 EPIDIDYMIDES 0.273 0.371 0.375 0.398 0.356 0.420 0.337 0.433 0.388 0.400 DuPont-5990 Company Sanitized. Does not contain TSCA CBI - 1207 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: II-l - 0 mg/kg/day ANIMAL NUMBER 650043 650044 650045 650046 650047 650048 650049 650050 650051 650052 650053 650054 650055 650056 650057 650058 650059 FINAL BODY 240.2 227.4 209.7 208.1 276.3 205.7 217.9 250.2 246.6 228.4 228.0 229.4 232.7 239.1 195.7 222.8 280.2 LIVER 11.269 9.388 9.615 8.588 12.625 8.885 10.539 11.484 10.623 10.350 9.307 9.341 10.095 10.691 9.156 10.787 12.019 THYROID GLAND 0.017 0.008 0.012 0.016 0.006 0.008 0.013 0.011 0.016 0.014 0.010 0.005 0.016 0.015 0.013 0.007 0.027 UTERUS 0.740 0.288 0.435 0.791 0.411 0.366 0.321 0.767 0.446 0.534 0.364 0.431 0.430 0.320 0.446 0.317 0.362 BRAIN 1.867 1.781 1.784 1.681 1.910 1.857 1.754 1.751 1.895 1.753 1.874 1.757 1.848 1.754 1.668 1.815 1.753 Fx ADULTS DuPont-5990 Company Sanitized. Does not contain TSCA O 03 ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: IV-1 - 25 mg/kg/day ANIMAL NUMBER 650060 650061 650062 650063 650064 650065 650066 650067 650068 650069 650070 FINAL BODY 211.0 262.4 262.1 226.9 235.8 217.2 230.1 225.6 223.0 242.1 243.4 LIVER 10.268 12.968 10.201 10.491 10.972 9.625 9.758 9.579 10.896 12.043 12.843 THYROID GLAND -1.000 0.017 0.015 0.010 0.008 0.006 0.020 0.014 0.007 0.014 0.005 UTERUS 0.376 0.407 0.550 0.331 0.576 0.499 0.384 0.414 0.343 0.467 0.330 BRAIN 1.847 1.851 1.761 1.912 1.786 1.853 1.802 1.786 1.874 1.812 1.874 ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI - 1209 - H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - F i ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grains) FROM FEMALE RATS GROUP: VI-1 - 100 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER THYROID GLAND UTERUS BRAIN 650073 650074 650075 650076 650077 650078 650079 650080 650081 230.9 207.0 276.0 251.3 218.6 225.1 273.4 239.6 222.3 10.575 8.030 12.765 12.764 9.674 8.941 13.027 10.899 10.144 0.003 0.014 0.007 0.016 0.005 0.009 0.019 0.008 0.009 0.563 0.443 0.384 0.419 0.405 0.340 0.322 0.381 0.647 1.763 1.748 1.803 1.811 1.818 1.809 1.891 1.808 1.747 DuPont-5990 Company Sanitized. Does not contain TSCA O 00 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM FEMALE RATS GROUP: II-l - 0 mg/kg/day ANIMAL NUMBER 650043 650044 650045 650046 650047 650048 650049 650050 650051 650052 650053 650054 650055 650056 650057 650058 650059 LIVER 4.692 4.128 4.585 4.127 4.569 4.319 4.837 4.590 4.308 4.532 4.082 4.072 4.338 4.471 4.679 4.842 4.289 THYROID GLAND 0.007 0.004 0.006 0.008 0.002 0.004 0.006 0.004 0.006 0.006 0.004 0.002 0.007 0.006 0.007 0.003 0.010 UTERUS 0.308 0.127 0.207 0.380 0.149 0.178 0.147 0.307 0.181 0.234 0.160 0.188 0.185 0.134 0.228 0.142 0.129 BRAIN 0.777 0.783 0.851 0.808 0.691 0.903 0.805 0.700 0.768 0.768 0.822 0.766 0.794 0.734 0.852 0.815 0.626 DuPont-5990 Company Sanitized. Does not contain TSCA Oro H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS RELATIVE ORGAN WEIGHTS (% Of body weight) FROM FEMALE RATS GROUP: IV-1 - 25 mg/kg/day ANIMAL NUMBER LIVER THYROID GLAND UTERUS BRAIN 650060 650061 650062 650063 650064 650065 650066 650067 650068 650069 650070 4.866 4.942 3.892 4.624 4.653 4.431 4.241 4.246 4.886 4.974 5.277 -1.000 0.006 0.006 0.004 0.003 0.003 0.009 0.006 0.003 0.006 0.002 0.178 0.155 0.210 0.146 0.244 0.230 0.167 0.184 0.154 0.193 0.136 0.875 0.705 0.672 0.843 0.757 0.853 0.783 0.792 0.840 0.748 0.770 DuPont-5990 Company Sanitized. Does not contain TSCA C8I - 1212- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM FEMALE RATS GROUP: VI-1 - 100 mg/kg/day ANIMAL NUMBER 650073 650074 650075 650076 650077 650078 650079 650080 650081 LIVER 4.580 3.879 4.625 5.079 4.425 3.972 4.765 4.549 4.563 THYROID GLAND 0.001 0.007 0.003 0.006 0.002 0.004 0.007 0.003 0.004 UTERUS 0.244 0.214 0.139 0.167 0.185 0.151 0.118 0.159 0.291 BRAIN 0.764 0.844 0.653 0.721 0.832 0.804 0.692 0.755 0.786 ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI - 1213- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP: II-l - 0 mg/kg/day ANIMAL NUMBER 650043 650044 650045 650046 650047 650048 650049 650050 650051 650052 650053 650054 650055 650056 650057 650058 650059 LIVER 6.036 5.271 5.390 5.109 6.610 4.785 6.009 6.559 5.606 5.904 4.966 5.316 5.463 6.095 5.489 5.943 6.856 THYROID GLAND 0.009 0.004 0.007 0.010 0.003 0.004 0.007 0.006 0.008 0.008 0.005 0.003 0.009 0.009 0.008 0.004 0.015 UTERUS 0.396 0.162 0.244 0.471 0.215 0.197 0.183 0.438 0.235 0.305 0.194 0.245 0.233 0.182 0.267 0.175 0.207 BRAIN DuPont-5990 Company Sanitized. Does not contain TSCA CBI - 1214- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP: IV-1 - 25 mg/kg/day ANIMAL NUMBER LIVER THYROID GLAND UTERUS BRAIN 650060 650061 650062 650063 650064 650065 650066 650067 650068 650069 650070 5.559 7.006 5.793 5.487 6.143 5.194 5.415 5.363 5.814 6.646 6.853 -1.000 0.009 0.009 0.005 0.004 0.003 0.011 0.008 0.004 0.008 0.003 0.204 0.220 0.312 0.173 0.323 0.269 0.213 0.232 0.183 0.258 0.176 DuPont-5990 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP: VI-1 - 100 mg/kg/day ANIMAL NUMBER LIVER THYROID GLAND UTERUS BRAIN 650073 650074 650075 650076 650077 650078 650079 650080 650081 5.998 4.594 7.080 7.048 5.321 4.943 6.889 6.028 5.807 0.002 0.008 0.004 0.009 0.003 0.005 0.010 0.004 0.005 0.319 0.253 0.213 0.231 0.223 0.188 0.170 0.211 0.370 DuPont-5990 Company Sanitized. Does not contain TSCA CBI - 1216- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX NN INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS -1217 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS EXPLANATORY NOTES Abbreviations SD = Sacrificed by design LESION GRADING: Histopathological changes are described according to their morphologic character, distribution and severity. The distribution (extent of tissue involvement) is* indicated, where appropriate, by modifiers such as focal, multifocal, diffuse, unilateral, bilateral, etc. A severity score, if appropriate, is also assigned as follows: MINIMAL: The amount of change present barely exceeds that which is considered to be within normal limits. MILD: In general, the lesion is easily identified but of limited severity. The lesion probably does not produce any functional impairment. MODERATE: The lesion is prominent but there is significant potential for increased severity. Limited tissue or organ dysfunction is possible. SEVERE: The degree of change is either as complete as considered possible or great enough in intensity or extent to expect significant tissue or organ dysfunction. COMMENT : Grades minimal through severe represent progressive involvement/severity along a continuum with minimal lesions being the least severe and severe lesions being the most severe. While the grades refer to the morphological characteristics of lesions, they also indicate their relative biological significance. Gross observations listing multiple masses for a tissue are distinguished with letters (i.e., A, b, c, d, etc.). - 1218 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646328 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING} GLANDS, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1219Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646352 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SEMINAL VESICLES - SMALL, RIGHT MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1220 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646357 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1221 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646358 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALI LY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1222 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646383 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE it THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1223 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646392 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1224 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P2 ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646395 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1225 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646402 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1226 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL # : 646408 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE A THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1227 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646409 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1228 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646424 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS : EPIDIDYMIDES TESTES ONE OF A PAIR PRESENT ONE OF A PAIR PRESENT THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, PROSTATE, SEMINAL VESICLES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1229 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL # : 646425 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1230 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646440 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1231 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL # : 646445 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, " TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1232 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646461 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1233 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646470 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1234 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646473 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1235 Company Sanitized. Does not contain TSCA CB1 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646479 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1236 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646480 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: ,NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1237 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 646490 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1238 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646326 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDSt EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1239 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646333 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES," TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1240 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646334 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1241 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646340 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE -1242 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646342 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1243 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646350 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1244 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646354 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1245 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646363 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1246 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646377 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE , THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1247 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646378 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE * THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE , SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1248 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646381 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE -1249 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646404 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSQOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1250 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P i ADULTS MALE RATS GROUP: I I I - O DOSE: 25 mg/kg/day ANIMAL # : 6 4 6 4 1 0 DAYS ON TEST: 1 0 4 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS : EPIDIDYMIDES TESTES ONE OF A PAIR PRESENT ONE OF A PAIR PRESENT THE FOLLOWING T ISS U E S WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, PROSTATE, SEMINAL VESICLES THE FOLLOWING T ISS U E S WERE AUTOLYZED; DEGREE OF AUTOLYSIS D ID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING T ISS U E S WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING T ISSU E S WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING T ISSU E S WERE IN SU F F IC IE N T FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1251 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646415 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE f THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1252 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646450 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1253 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646467 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1254 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646478 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1255 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646483 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1256 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646486 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1257 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 646493 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS : EPIDIDYMIDES TESTES ONE OF A PAIR PRESENT ONE, OF A PAIR PRESENT THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, PROSTATE, SEMINAL VESICLES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1258 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646330 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1259 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646336 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): TESTES - SOFT, BILATERAL MICROSCOPIC OBSERVATIONS: EPIDIDYMIDES MODERATE TESTES BILATERAL, MODERATE - OLIGOSPERMIA/GERM CELL DEBRIS, BILATERAL, - DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, PROSTATE, SEMINAL VESICLES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN -1260Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL # : 646338 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE -1261 Company Sanitized. Does not contain TSCA CB H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646341 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: EPIDIDYMIDES TESTES - ONE OF A PAIR PRESENT - ONE OF A PAIR PRESENT f THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, PROSTATE, SEMINAL VESICLES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1262 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646348 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1263 Compny Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 -INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646353 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE l^HE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1264Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646356 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1265 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646366 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1266 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646375 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: PROSTATE - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, EPIDIDYMIDES, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1267 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646387 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1268 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646390 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1269 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646394 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: EPIDIDYMIDES TESTES - ONE OF A PAIR PRESENT - ONE OF A PAIR PRESENT ' THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, PROSTATE, SEMINAL VESICLES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1270 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646400 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE {selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE*UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1271 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646417 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1272 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646429 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1273 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646447 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1274 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL # : 646465 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1275 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646476 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1276 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646496 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1277 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 646499 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1278 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646332 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1279 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646351 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1280 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646359 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1281 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646362 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1282 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646365 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1283 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646382 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1284 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646386 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE * THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1285 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646393 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1286 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646401 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE T H E 'FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1287 Compiny Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646405 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY:* NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1288 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646406 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES'WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1289 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646418 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1290 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P2 ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646441 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE! SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1291 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646451 DAYS ON TEST: 106 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1292 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL. #: 646452 DAYS ON TEST: 105 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1293 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646491 DAYS ON TEST: 103 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1294 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646497 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1295 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 500 mg/kg/day ANIMAL #: 646498 DAYS ON TEST: 104 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1296 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646503 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SALIVARY GLANDS - DISCOLORATION, TAN, FIRM, RIGHT; 1.0 CM DIA MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1297 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646520 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1298 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646526 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1299 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646544 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1300Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646550 DAYS ON TEST: 127 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE -1301 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646552 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINAT IO N : NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1302 Company Sanitized. Does not contain TSCA CB1 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646557 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE , THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1303 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646569 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1304Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646575 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1305 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646585 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1306Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646591 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1307 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646604 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE ,, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1308 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646606 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1309 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646622 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE Th e FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: n o n e THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE -1310Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646644 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions) STOMACH - DISCOLORATION, BLACK, FEW, GLANDULAR; <5MM LINEAR MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1311 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 646646 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1312 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646651 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1313 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pa ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646653 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1314Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646654 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE! FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1315Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 646668 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: , NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1316Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646504 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1317 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646529 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1318 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646543 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1319Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646553 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1320Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL # : 646554 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN -1321 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646558 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1322 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646559 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1323 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646561 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1324Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646564 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1325 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646573 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIE|, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1326 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646579 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): STOMACH - DISCOLORATION, BLACK, FEW, GLANDULAR; <5MM LINEAR MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1327 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646584 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1328 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646587 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1329 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646596 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions) NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1330 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646598 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1331 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646603 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1332 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646631 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): PITUITARY GLAND - LARGE, MODERATE MICROSCOPIC OBSERVATIONS: NONE tTHE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, 'VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1333 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646638 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1334 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646670 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1335 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 646672 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): MAMMARY GLANDS - MASS, TAN, FIRM, VENTRAL, NECK; 2CM DIA MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1336 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646521 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE STOMACH SKIN (selected lesions): - ULCER/EROSION, FEW, GLANDULAR; < 3MM LINEAR - ALOPECIA, BILATERAL, FRONT, REAR, LIMB; ABDOMEN MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1337 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646524 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE -FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1338 Company Sanitized. Does not contain TSCA CB! H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646527 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1339 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646546 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SKIN - ALOPECIA, ; HINDQUARTERS MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES JiERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1340Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646547 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE > THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1341 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646555 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: UTERUS - HYPERPLASIA, CYSTIC ENDOMETRIAL, MINIMAL - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID "NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1342 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: V I -0 DOSE: 100 mg/kg/day ANIMAL #: 646589 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FQLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1343 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646590 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): PITUITARY GLAND - LARGE, MILD MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA ' THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1344 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646594 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1345Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646600 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1346 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646605 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1347 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646607 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE URINARY BLADDER KIDNEYS (selected lesions): - CALCULUS, SEVERE - CYST, FEW, CLEAR, - CALCULUS, SEVERE, BILATERAL BILATERAL, SEVERE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID'NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1348 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646615 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1349Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646645 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1350 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646647 DAYS ON TEST: 124 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1351Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646648 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1352 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646661 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1353 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646666 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): PITUITARY GLAND - LARGE, MILD MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERJJS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1354 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646671 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1355 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 646675 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE tfHE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1356Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646512 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): LIVER - LARGE, MODERATE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY; NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1357 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646532 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): LIVER - LARGE, MODERATE SKIN - ALOPECIA, VENTRAL BODY; HINDQUARTERS MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1358 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646539 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1359 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646563 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SKIN - STAIN, BROWN; SURROUNDING MOUTH MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN -1360 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646566 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1361 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646570 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SKIN - ALOPECIA, MILD, VENTRAL BODY MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: QVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DIDJ\TOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1362Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL # : 646572 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SKIN - ALOPECIA, VENTRAL BODY MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WE'RE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1363 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646574 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1364Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646582 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SKIN - STAIN, YELLOW, PERINEUM MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1365 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P2 ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646583 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1366 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646602 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SKIN - ALOPECIA, VENTRAL BODY MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1367 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646616 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1368 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646619 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1369 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646623 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1370 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646628 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1371 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646640 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SKIN - STAIN, YELLOW, PERINEUM MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, ,UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN - 1372 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646641 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1373 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646655 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1374 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646662 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1375 Company Sanitized. Does not contain TSCA CBi H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 500 mg/kg/day ANIMAL #: 646663 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1376 Company Sanitized. Does not contain TSCA CBJ H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX OO INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, PUPS - 1377 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi PUPS EXPLANATORY NOTES Abbreviations FD Found dead - 1378Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - F i PUPS DAM GROUP: I I - O DOSE: 0 MG/KG/DAY DAM ANIMAL NUMBER PUP SEX PUP ANIMAL NUMBER DAYS ON TEST FATE OBSERVATIONS No pups were found dead in this group. - 1379 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx PUPS DAM GROUP: IV-0 DOSE: 25 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 646596 F 649651 -21 FD 649652 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED LUNGS - NOT EXPANDED - 1380Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. PUPS DAM GROUP: V I - 0 DOSE: 1 0 0 MG/KG/DAY DAM ANIMAL NUMBER PUP SEX PUP ANIMAL NUMBER DAYS ON TEST FATE OBSERVATIONS 6 4 6 5 4 7 F 6 4 9 6 7 3 - 1 7 FD 6 4 6 6 7 1 F 6 4 9 6 7 2 - 2 1 FD 6 4 6 6 4 5 M 6 4 9 6 6 1 - 2 1 FD 649662 - 7 FD F 6 4 9 6 7 1 - 2 1 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED NO ABNORMALITIES DETECTED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED NO ABNORMALITIES DETECTED WHOLE BODY - AUTOLYSIS, SEVERE - 1381 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx PUPS DAM GROUP: VIII-0 DOSE: 500 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 646662 F 649697 -14 FD 646641 M 649681 -21 FD F 649691 -21 FD 646572 M 649682 -21 FD 646566 M 649683 -21 FD 646655 M 649684 -21 FD F 649692 -21 FD 646663 M 649685 -21 FD F 649693 -21 FD U 649686 -21 FD 646574 F 649694 -21 FD 649695 -21 FD 649696 -21 FD STOMACH - NO MILK SPOT WHOLE BODY - AUTOLYSIS, SEVERE STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED WHOLE BODY - AUTOLYSIS, SEVERE STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED WHOLE BODY - AUTOLYSIS, SEVERE WHOLE BODY - CANNIBALIZED, ; ONLY HEAD REMAINS STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED WHOLE BODY - CANNIBALIZED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED - 1382 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX PP INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS - 1383 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj WEANLINGS EXPLANATORY NOTES Abbreviations SP = Sacrificed by design; necropsy performed - 1384 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F i WEANLINGS ANIMAL NUMBER MALE RATS DAYS ON TEST FATE GROUP: 1 - 1 DOSE: 0 MG/KG/DAY OBSERVATIONS 650094 650095 650096 650097 650098 650099 650100 650101 650102 650103 650104 650105 650106 650107 650108 650109 650110 650111 650112 650113 650114 650115 650116 650117 650118 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1385 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: 1 - 1 DOSE: 0 MG/KG/DAY OBSERVATIONS 650119 650120 650121 650122 650123 650124 650125 650126 650127 650128 650129 650130 650131 650132 650133 650134 650135 650136 650137 650138 650139 650140 650141 1 SP 1 SP 1 . SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED .NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1386Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: III-l DOSE: 25 MG/KG/DAY OBSERVATIONS 650196 650197 650198 650199 650200 650201 650202 650203 650204 650205 650206 650207 650208 650209 650210 650211 650212 650213 650214 650215 650216 650217 650218 650219 650220 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1387 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F x WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: III-l DOSE: 25 MG/KG/DAY OBSERVATIONS 650221 650222 650223 650224 650225 650226 650227 650228 650229 1 SP 1 SP 1. SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1388 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: V-l DOSE: 100 MG/KG/DAY OBSERVATIONS 650261 650266 650267 650268 650269 650270 650271 650272 650273 650274 650275 650276 650277 650278 650279 650280 650282 650283 650284 650286 650287 650288 650289 650290 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP WHOLE BODY - SMALL NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1389 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: V-l DOSE: 100 MG/KG/DAY OBSERVATIONS 650291 650292 650293 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1390 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj . WEANLINGS ANIMAL NUMBER MALE RATS DAYS ON TEST FATE GROUP: V I I - 1 DOSE: 5 0 0 MG/KG/DAY OBSERVATIONS DuPont-5990 650333 650334 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED -1391 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: II-l DOSE: 0 MG/KG/DAY OBSERVATIONS 650142 650143 650144 650145 650146 650147 650148 650149 650150 650151 650152 650153 650154 650155 650156 650157 650158 650159 650160 650161 650162 650163 650164 650165 650166 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1392 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: II-l DOSE: 0 MG/KG/DAY OBSERVATIONS 650167 650168 650169 650170 650171 650172 650173 650174 650175 650176 650177 650178 650179 650180 650181 650182 650183 650184 650185 650186 650187 650188 650189 650190 650191 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1393 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: II-l DOSE: 0 MG/KG/DAY OBSERVATIONS 650192 650193 650194 650195 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1394 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: IV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 650230 650231 650232 650233 650234 650235 650236 650237 650238 650239 650240 650241 650242 650243 650244 650245 650246 650247 650248 650249 650250 650251 650252 650253 650254 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1395 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: IV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS DuPont-5990 650255 650256 650257 650258 650259 650260 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED - 1396Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj WEANLINGS ANIMAL NUMBER FEMALE RATS DAYS ON TEST FATE GROUP: V I - 1 DOSE: 1 0 0 MG/KG/DAY OBSERVATIONS DuPont-5990 650298 650299 650301 650302 650305 650306 650307 650308 650309 650312 650313 650314 650315 650316 650317 650318 650319 650320 650321 650322 650323 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED - 1397 Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F x WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VIII-1 DOSE: 500 MG/KG/DAY OBSERVATIONS 650340 650345 1 SP 1 SP WHOLE BODY - SMALL NO ABNORMALITIES DETECTED - 1398 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 APPENDIX QQ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj ADULTS - 1399 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS EXPLANATORY NOTES Abbreviations FD = SD = Found dead Sacrificed by design - 1400 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS 649992 649993 649994 649995 649996 649997 649998 649999 650000 650001 650002 650003 650004 650005 650006 650007 650008 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1401 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS MALE RATS GROUP: III-l DOSE: 25 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS DuPont-5990 650009 650010 650011 650012 650013 650014 650015 650016 650017 650018 650019 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, MODERATE, RIGHT, PELVIS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED - 1402 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS MALE RATS ANIMAL DAYS MODE OF NUMBER ON TEST DEATH GROUP: V-l DOSE: 100 MG/KG/DAY OBSERVATIONS 650020 650022 650023 650024 650025 650026 650027 650028 650029 650030 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1403 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS MALE RATS GROUP: VII-1 DOSE: 500 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS DuPont-5990 650032 650035 650036 15 SD 13 SD 3 FD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED WHOLE BODY - SMALL - 1404Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fa ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS 650043 650044 650045 650046 650047 650048 650049 650050 650051 650052 650053 650054 650055 650056 650057 650058 650059 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5990 - 1405 Company Sanitized. Does not contain TSCA CSI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: I V - 1 DOSE: 2 5 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS DuPont-5990 650060 650061 650062 650063 650064 650065 650066 650067 650068 650069 650070 40 SD 40 SD 40 SD 4 0 SD 40 SD 40 SD 40 SD 40 SD 4 0 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED t NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED - 1406 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fa ADULTS FEMALE RATS ANIMAL DAYS MODE OF NUMBER ON TEST DEATH GROUP: VI-1 DOSE: 100 MG/KG/DAY OBSERVATIONS DuPont-5990 650073 650074 650075 550076 650077 650078 650079 650080 650081 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED - 1407Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F 1 ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 500 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS 650083 650086 650087 5 FD 13 SD 2 FD SKIN - STAIN, YELLOW, PERINEUM, INGUEN WHOLE BODY - SMALL NO ABNORMALITIES DETECTED STOMACH - DISTENDED WITH GAS SMALL INTESTINE - DISTENDED WITH GAS LARGE INTESTINE - DISTENDED WITH GAS SKIN - STAIN, YELLOW, PERINEUM, INGUEN WHOLE BODY - SMALL - 1408 Company Sanitized. Does not contain TSCA CBI
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