Document 2Dp6a1JbBOoyYRd3pMV8GeJ6

N gnn nil PONT USE ONLY AR226-2893 F 1. du Pont de Nemours and Company Haskell laboratory or Toiicology ami Mellclne Haskell `-lktoni'aoad> Kewark. Delaware 19U1 HASKELL LABORATORY REPORT NO. 12H g-..ar Tn< tiated/Completed 1/7/81 - 2/IB/Hi `Chemicals i figments Dept. Jackson Laboratory rnjai. LD50 TEST IN RATS Procedure: The test material, as an if yowg^duirCrllcM intragastric intubation in divided o s e ^ ^ ^ S ^ determine the initial dose f S T t l i S ? T?e surviving rats were weighed and observed during a 14-day recovery period and then sacrifi . Results: Dose (mg/kg) 25,000 Average Body Weight (g) 252 Solution 00 69 Average Dose (ml) 9.13 Mortality Ratio 0/10 LD50 > 25,000 mg/kg Clinical Signs: , 25.000 mg/kg: Salivation and slight weight loss. __________ _ ------- very low toxicity when administered orally HJESLLLl J in divided doses; its LD50 is greater than S . K V k s . biiy" " it, the maximum feasible doee. Clinical signs included: salivation and slight weight loss. ( V. - 1- Company Sanitized. Does not contain TsrtA * M A Range Finding Study using 1 rat per dose level produced no deaths when administered from 670 to 25,000 mg/kg, the maximum feasible dose level. i. i- j . !Approved by? odu^xi L X-________ j Gerald L. Kennedy ' Chief, Acute Investigations Section JAH:jrg ' Study Director: 0, L. Dashiall I at^Iasu|d^^ahruary 23, 3j981 o r t No. 120-81 2Company Sanitized. Does not contain TSCA CBI