Document 1gEm7GjdBKM7r938eEYyNqRDK
Week P re v , 10/25 11/1 1 1 /8 11/15 P re v. Ending Month 11/1 11/8 11/15 11/22 Month
H /1 11/8 11/15
11/8 11/15 11/22
4
aas..
o*n
A
ZHC-5t 9
U"\ CN *-4
2 O --*
M
0\ D <N O O <H
s s CN CN CN
OS *9 CO
(S H H
r4
< CN
O' iH
11/8 11/15 P rev. 11/15 11/22 lonth
2 READING > 25 PPM I
m >- o
< Ss
s s s: u pa
=. y>* a sO
u i-l c. 5 %j ^l t w ^<?lj ^ ! ^ 3 si
> CJ >
>5 2g a- X m*H CcNn
fr-t4 ti---l4
fs0iu4 oH
V
zt-s4 U \
9 CN W 3 rOH pH N
11/1 i 11/8
U /8 11/15
10/25 11/1
8/TT T/TT
cOn.' mC.O .nSO m m n o o cn o.imn..nfn
ScOn. sr m o s
mOm)
os* CO
<Cos3.
o.i.n .m mcoc<or acn)
fivsO*cio-H*icov<O-(
*sC-oO m *coo rcs-Ool
o
2 B
Ors \o O^
r^-
o co CO r*~
r* r-
co.m..m os oo fN.
in. co
>Ctc:sj
hiNe nlln
" I Cu
t-i *
cJ-3u3> 0><
LONG BEACH
Pzn-1 -2
Roof
PLANT AVG.
BFG27191
23775003
co*cn O>-( O 00 * o o Os <N sO OHO
r*,. <*> Os O
OO HCO HCN*
so so O r-l O
'joe CN cn CN
i~4
n.
r->. CN
93.1 97.6 90.3 91.9 92.9 95.8 92.1 95.1
cmo.v.O .<oi on Cs os
ro-o4 Cn
co.v.o .co cn ^ cn
sO CO CN
rl CN --4
C.^..i-4 m sr
i-m*.
OS
A
so. <r
--
[--
^
CIh MH
WEEKLY SUMMARY
VC1 Ambient Vapor Concentrations LOUISV :lle
Week Ending
AVERAGE
% READING < 10 PPM
. % READING > 25 PPM
2 READING > 50 PPM
Prev. 10/25 11/1 11/8 11/15 Prev. 10/25 11/1 11/8 11'15 Prev. 10/25 11/1 11/8 11/15 Prev. 10/25 11/1 Month 11/1 11/8 11/15 11/22 Month 11/1 11/8 11/15 11 '22 Month 11/1 11/8 11/15 11/22 lonth 11/1 11/8
1-1 -2 -3
Avg.
15-1 - -2
-3 Avg.
111-1 -2 -3
Avg.
*115-2 Avg.
121-1 -2 -3
Avg.
PLANT AVG.
4.8 5.0 5.0 2.5 2.0 3.0 7.0 8.0 7.0 4.8 5.0 5.0
4.5 3.0 2.0 6.0 5.0 4.0 6.3 4.0 4.0 5.6 4.0 3.3
5.0 4.0 4.0 4.3 5.0 4.0 4.8 5.0 5.0 4.7 4.7 4.3
21.5 22.0 16.0 21.5 22.0 16.0
3.5 5.0 3.0 4.3 4.0 3.0 4.3 4.0 5.0 4.0 4.3 3.7
8.1 8.0 6.5
93.7 97.2 81.1 90.7
94.3 96.4 80.7
90.5
88.0 94.6 84.1 88.9
90.2 83.3 84.2 85.9
98.8 95.8 95.4 96.7
98.8 93.5 94.6 95.6
92.4 94.6 92.6 91.7 92.4 *91.7 92.5 92.7
94.6 93.7 93.3 93.9
18.8 18.8
4.9 20.0 4.9 20.0
92.3 92.2 91.6 92.0
86.9 92.3 90.5 89.9
95.2 92.9 94.3 94.1
76.0 74.9 78.5
2.5 0.9 1.1 0.9 4.6 3.9 2.7 1.9
4.2 0.0 4.6 1.5 2.7 0.8 3.8 0.8
3.0 1.2 2.3 2.7 2.2 2.0 2.5 2.0
22.4 24.9 22.4 24.9
2.6 2.4 3.5 1.6 1.9 1.2 2.7 1.8
2.1 2.7 2.4 2.4
0.0 1.2 0.6 0.6
1.2 2.4 3.0 2.2
4.3 4.3
1.2 1.2 2.1 1.5
6.8 6.3 2.2
1.0 0.9 0.6 0.8 0.0 1.2 1.4 1.2 0.6 1.1 0.7 0.8
1.5 0.0 0.0 1.4 0.6 0.0 0.4 0.2 0.6 1.1 0;3 0.2
1.5 1.2 0.6 0.9 1.2 1.2 1.1 1.2 1.8 1.2 1.2 1.2
2.5 2.2 0.0 2.5 2.2 0.0
1.0 0.3 0.9 2.0 0.6 0.6 0.5 0.0 0.6 1.2 0.3 0.7
1.4 0.9 0.6
tV O S sLLS Z
* Workers not normally in this building all shifts
only one m.in per shift and about 35% of hia time Is spent in building.
BFG27J92
VC1 Am bient V apor C o n c e n tra tio n s
Week
E n d in g
10/25 11/1 L l/8 11/15
11/1 11/8 11/15 11/22 3.7
C0Uo A oz
s
>v*c5
C*l. 5TT
rOt OO' Ho
o>.i*.n .n CN O' vO
\O0
tn >H
h
i--.1
O M.H..H
-** -T* O*' HNH
vD VO <0 fH Ha H
pH CHO
10/25 11/1 11/8 11/15 11/1 11/8 11/15 11/22
Acu. Wl A zV
2J
NO
O'
HNH
OUO (N. rH CO
H.O..r- m mCS pH on in.n.> v.o
nn n
mm
CO.O.O .CO in.n.* .vo
o CO CO
o
cu
*
o
V zv
(*) O I'l
*
OO' ON' <O'
tn co co hCC.mu."> V.cDo
*HC*O
CO O' vO
-OT' *000 OCON
O.' -O..Ol pCHO sOo' IN*
80.7 81.9
11/8 11/15 Prev. 10/25 11/1 11/8 11/15 11/15 11/22 Month 11/1 11/8 11/15 11/22
83.9 77.2 80.6
AVG. 7.5 7.1 8.5
513-2 88.1 -3 73.4
A vg . 80.8
3
ui
%
8/T T T /T T
m <r O'
n -j n
vo n o co co
tH r-H
O' CN
en m
NNO 00 O' O'
10/25 11/1
O N mom vD O' t- 1C (S N
P re v .
Month
HN 1 1 00
CNJ > p*/-) <
PLANT
7.4
237
N
BFG2719
VC1 A m bient Vapor C o n c e n tra tio n s 9 0 .9 9 0 .9 9 6 .0
un CM rH CM
CO
CO
m
CM
O
>5 2g
cm
m cm i-l CM
O cn o ooo
oooo o ood
oooo
oo o
o dd
O O CM #H
..O. oo
o a
oo
co
o
o
o m
o
CO
m
CM rH
a h
>*s
81
m cm rH CM
00 fmt
i--I rH CO
m
CM rH O rH
>01 *ffl &n* ,s2c
m cm <H CM
cc m
co cn o o
do d o o
CM
O *
a
oHNn
I
**
o
r*a
CM CO m rH On ON CO O'
o m co *a a a
o O ON ON
rH O CM
n h is is ON ON fs CO
O O CM CM CM CM O' O' On
CM -O aaaa
o m co CN O' H rH
ON
CM CM co
O
CM CM ON ON
ps fs On ON
cn o
On
m
rH CO
in
CM O <-t
> 4-1
2- oc
C
0a); -H 3 uCi
r**. r*. no
CO CO CO CO
cm cm cn 00 CO 00 00
00
ifl Oi id O r f-. co co
r> co o ft IS N CO CO
CM CM
On MT
!* ON
O H ON ON
n fs a fs. fSi
n 00
cm m
ll
>
*4- <
3
cm r~) I I C-J
*W0-
m.
rH
^ -5
d?
Cm
23775006 BFG27194
BFG RESTRICTED
CALVERT CITY Ueek Ending
AVERAGE
Prev. 10/21- l0/2( Month 10/27 11/3
1
-1-----
1
Chromatograph Houses Caustic Scrubber Area
T 6
S 4
(Aiench Areas
3 _2___
VCM Column Areas Refrigeration Machine
6-, 02____ 34
Tank Farm Areas Loading Rack Areas
0 1_J___ _i____
6
1
6 8 5 2 1
cc:
CLUoode
JJSchonaerts CEEvens
RASpurlock CDSchaaf NUaiteaate JRRender
03
T1 Q N->
\D
WEEKL*
:SUMMARY
Ambient Organic Vapor Concentration*
X RE ADING 10 PPM
Prev. 10/21 10/26 Month 10/27 11/3
9B_
100
9Q
78
91 82-
69 91
98
-91 ,90..|
94
9376.91.-
100 79
92
-94- 9799 100
98
100
X READING > 25 PPM
Prev. 10/21 10/2* Month 10/27 11/3
P 0- 0
2 -.7- 5 3 40 3 00 -3 11 10
1 46
3 02
0 00
X READING > SO PPM
Prev. 10/21 10/2 > Month 10/27 11/3
n ft 0 110 22 0
00 0 26 8
12 4
200 00 0
fO
to
-n]
a
o SJ
RESIDUAL vci content OF FINISHED PVC PRODUCTS
DISTRIBUTION
-- David Brooks
y A. W. Clements
--' C. B. Cooper
L. B. Crider
A. M. Fairlie
R. J. Fawcett
C. R. Flynn
E. W. Harrington
M. N. Johnson
E. B. Katzenmeyer, Jr.'
F-. E. Krause
R. W. Kreager P. H. Lawrence
R. W. MacCusple-
J. F. Malone
J. L. Nelson
H. R. Rex
R. N. glands
G. D. Schaaf
E. G. Schwaegerle
R. D. Scott
R. W. Strassburg . R. L* Toole
A. Vlttone
P. J. Weaver
A. R. Webber
W. J. WilcoxJ
:
C. L. Woods
B. M. G. Zwlcker
R. J. Coffey W. M. Smith
R. A. Krueger
23776001
BFG27196
-u
> J <"
=!!
si ^
o
rOn r-
aCN
U-
o> CN sO
CN
<N <ys MN
r - - *-------- -
CN <<or -4a.
co1
'' 2<%o. I : aoos
'
a-<sr,1
; M776pi|Z..si
Os -gi-
ckOo::
lO (S --< CN
av.. _
CN vO
<"t. .CN
CN 0 CN. CN
-- --------- cni------- 1------- i-
[I I cO
` |I 2*o1
: - jw
...ki _ \i
;$rr~ H rH -- a)
a
Ii
-----^
VIVa Q3HDVIIV 33S
<c r.
_u_
4 - v.T.vrr rmrtVTTV
L
.
.
j
-j -
-
-M
1
-j..
_
-'i _
i
i ~a-
*<nH cCnN r T -j - yivp oprovuy 33s p
aCNs vO 1r--N1 ' CNH
Ui-H-T- TCJN
as
r- CN
cn as CN CN
so CN -H CN
I!:1 !i;i
i
11 11
1 <21
iS!5!
1
!
1ii ! M ! !1! |
!!lli
: col i ! 1 t 1 1 ` 1 ! 1 1 :
PKKMirCrcJv
T ^ TN 'ST
533
---------i-n-TN'
!
esr
-iro--i*/--vt osa -
.I
i
;
!'1
1
1^ al
1 1
1!I1
1!
1 CN'
! Jl
--l_SL__ L.
! I SI I
. ,t
__ Li-iOt
*'}** i
1 t r1 i
!I r *T
? N25ivi soniayaHi om --\ mpa h<iv?30ivwohh?
11
CN
S. .CN
cn as
CN.CN
--L--L-.L
yiva aarovuv 33s ]--i--1-
II
xjyjias
!i
sO <N --* 1 CN
a3 gw
Vqj
r
sol <0 cnI Os x- X Os. Os
SpSf^'il i
f4 - viva craiDj/uv s^s t j TT f-h-r-!--r
ij ]! _ '
<0 sof CO I M\ 'pHtP X] co
vi o Wi w Ui V, u w
<**.
i!
1! !
1ii: 1 i |j j| j j i 11
11 1
1 i
-L
Cd
tfl 1 1 -1-Ui
UJ 10
44-
;1 5;
u wO CO
-10.! 14 p
> --
-4 ! to
l xi O , CO o)
X ~vjr~u soii; w 1; w0*, nH
RESIN
AVON LAKE
| TYPE
11/15
rfeek Ending 11/22
-- - OFFiGRADE
\
; ic !
1
11/22 11/29 1
;
11/2 9 12/6
' 2BEI j 92C
300) 6B j ^221
ii Ij i1
11
; 2224
1 4271
42 7( !
; '
1 1
j
1i~
--
tX T1 o v-oo
-
SO oo
--
r1- -1 -
i ii __ -
-- 1 --i `
1 1
i I 1 nr
i__ i --j
if
i1
i (r
. . . |"
i
i 1-- -
--
i ;
-
^- -
I!
1 Residual
!
vci
conteni
of
rnui siiKn
1
I
pvc
i
products
:
1
PACE 2
ii ii!/15; 11/22!
- ---
Data Expressed in PPM VCI ! !
HENRY ! ! !
! LONG BEACH
|
; 11/22; lJl/2 !> li/29: 12/6
11/lt !" '22 1 run In '29*
.1/ 2/
..... -- -- --
54
.
1
i
i1 r il
1
\; :1
!
LOUISVILLE
| PEDRICKTOUN
11/15 11/22
----
1
11/22
'11/29
;
1
11/29
12/6
1
48/3
"
6
l3 1
104 :
3142
11
5489
1 123
!
' i
1
. 11T9
1
.j;
T
l
1
i
11 "
;
- - (1
11/15 11/22
11/22 11/29
11/29 12/6
..J__:i.
-1!11
! 1
IT
1
,! 11
i
1
t
j I
i`
I l
'
'
-
1
-- --....
-- -----
--" __
*"* --. _i
*-- --
----
-- "--'
--
--i j i1
... .... -
--!
----
--- -
i
----
.... --
-
j-- -- ...
.. j -
m
" -
:
"
- " --
--
1r j
1_
l!
fi j
r-- -
E
1 f;:
Sh op 0o3
11
RESIDUAL VC1 CONTENT OF FINISHED PVC PRODUCTS Data Expressed In PPM VC1
PLANT: Avon Lake WEEK ENDING: 11-22-74
Resin Type
No. Data Points
G-92 102EP F-5 103EP F-76 110X233 110X333 121 124 F-l 430X30
WEEK ENDING: 11-29-74
102EP F-S 103EP F-76 G-92 110X333 121 124 124 F-l
13 22 18
1* 3 8 11 4
23 20 13
2 10
1 8
WEEK ENDING: 12-6-74
102EP F-5 103EP F-76 G-92 110X333 121 124
19 13 16
1 10
5
Average
97.4 229.7
9.9 3.9 2.6 4.4 26.5 302.3
High
566.0 633.0
27.1 3.9 3.9
15.1 63.4 544.0
Low
0.5 6.3 3.9 3.9 0.5 0.4 8.9 213.0
359.1 10.4 56.1 3.8 3.5 25.8 49.2
3195.0
97.6 285.0
4.9 7.4 25.8 140.0
0.6
0.2 0.3 2.7 0.9 25.8 5.8
266.4 5.8
74.6 3.1
10.8 100.0
996.0
21.2 373.0
3.1 30.0 157.0
0.2 0.4 0.4
3.1 1.6 17.7
23776004
BFG27199
RESIDUAL VC1 CONTENT OF FINISHED PVC PRODUCTS Data Expressed In PPM VC1
PLANT: Louisville
WEEK ENDING: H-22-74
Resin Type
No. Data Points
G-92 103EP 103EP F-76 110X402 121 126 135 202 300X6 603X560
7
23 6 2 3 1 2 5 3
IS
WEEK ENDING: 11-29-74
G-92 101 F-4 103EP 300X6 603X560
e
5 24
3 12
WEEK ENDING: 12-6-74
G-92 101 F-4 103EP 103EP F-76 110X285 121 126 135 202 300X6 603X560
4
12 14 11
1 3 2 13
23
10
Average
1.4 230.2 183.3
72.0 7.7 6.0 3.0
3489.4
1807..27
High
6.0 467.0 221.0 106.0
15.0 6.0 3.0
4013.0 295.0 2.0
Low
0.0 7.0 119.0 38.0 1.0 6.0 3.0 2541.0 104.0 0.0
1.1 3543.8
290.2 256.0
0.1
2.0 4403.0
771.0 299.0
1.0
0.0 3097.0
56.0 227.0
0.0
3.0
2821.7 274.3 181.3 47.0 21.3 3.0 3.6
2397.5 181.3 0.2
12.0 4487.0
645.0 290.0
47.0 33.0
3.0 8.0 3624.0 217.0 1.0
0.0 659.0
21.0 75.0 47.0 12.0
3.0 2.0 1171.0 113.0 0.0
23776005
BFG27200
METABOLISM QF VINYL CHLORIDE
Watanabe, P. G.1, Hefner, R. E. Jr.2, McGowan, G. R.3 and Gehring, P. J.4 Presented at the Conference of the Combined Clinical Staffs, National Institute of Health, Bethesda, Maryland
November 14, 1974 1,J*Toxicology Research Laboratory
1803 Building 2Organic Chemicals Research
3Analytical Laboratory The Dow Chemical Company Midland, Michigan 48640
These studies were funded in part by the companies supporting the vinyl chloride projects being administered by the Manufacturing Chemists Association, Washington, D.C.
BFG27203
23778001
METABOLISM OF VINYL CHLORIDE (VC)
Angiosarcomas, 2ymbal gland carcinomas and nephroblastomas developed in rats following exposure to 50-10,000 ppm VC 4 hours per day, 5 days per week for 12 months and sub sequently maintained and observed until death (Maltoni and Lefimine, 1975). The incidence of tumors at 50 ppm was less than that predicted from a log dose-response curve generated from the tumor incidences at higher ex posure levels of 250-10,000 ppm. Considering the decreased observed versus expected tumor incidence at 50 ppm together with the fact that VC per se is not a potent alkylating agent led to the hypothesis that the carcinogenic potential of VC may be mediated through the formation of reactive metabolites. Therefore, studies were designed to elucidate the fate of inhaled VC in rats.
A 4.7 liter plexiglas inhalation chamber was constructed
such that 4 rats could be simultaneously exposed to various concentrations of VC. To minimize contamination of fur and skin, only the nares of the rats protruded through a rubber membrane into the chamber. The appropriate initial concen tration of VC (Matheson Gas Products, 99.9% pure) was generated
BFG27204
23778002
2- -
in the chamber and continUpusly analyzed by circulation through an infrared spectrophotometer (Wilks) set at 10.9p. Carbon dioxide was continuously removed from the recirculating system by absorption on an Ascarite column. Filtered air was metered into the system to replenish the oxygen con sumed. Since the amount of air consumed was within 10% for all experiments, respiratory parameters were not signifi cantly changed over the approximate 1 hour exposures. Rats used in these studies were Sprague-Dawley, Spartan substrain ranging in weight from 165-200g.
Disappearance of VC from the recirculating inhalation chamber, resulting from uptake and subsequent metabolism, occurred according to apparent first order kinetics as described by: - dC = kC. In this equation C is the concentration of VC (ppm) at time t (minutes) and k (minutes ^) is the rate con stant for the decline in concentration. The rate of dis appearance of VC and the corresponding half-life (t^^) was calculated from the slopes of the log concentration-time curves. The rate of disappearance of VC from the chamber was slower at concentrations of 1000 ppm than 50 ppm (Figure 1). Other experiments using initial concentrations ranging from 50-105 ppm VC revealed a linear disappearance with a
BFG27205
3778003
B.F.GOODRICH CHEMICAL COMPANY 197^ VCM IERSONNEL MONITORING DATA
iV^ '
Plant AVON'LAKE
Date Reported
9/23 9/30
loM
10/14 10/25 11/01 11/08
No.. Monitored Carbon
OVA Tube Total
34 15 18 10
50 14 26 0
33 0 35 0 23 0
49 28 64 26
33 35 23
Readings, ppm
High Lov Average
1500 80
55 250 100 1000 100
6 4
1 3 1.5 2
3
48.0 12.9
9.0 16.0 11.2 15-0 10.8
No. Monitored
>25 PPIQ
21 7 9
16 12
9 5
CALVERT CITY HENRY
8/25 9/01 9/08 9/15
9/23 10/01 10/07 10/l8 10/22 10/29 11/07 11 /l4
0 85
85
302 0.1 23.8
0 85 85 285.5 0.1 18.8
0 85
85
830 0.4 33.2
0 38 38 218.9 0.5 15.1
23 15 4 29
36 4
27 2 25 2
25 2 35 1 28 3
38 33 40
29 27 27 36 31
110 1000
1000 200
30 40 200 70
3 10.0
3 9.7 4 12.4 C/ 11.6 7 9-4 4 12.3
2 8.7
2 9.3
12 10 13
3
0 10
6 6 4 C
s
2 3
LONG BEACH
9/21
15 12
27
1000 4 8.7
1
LOUISVILLE
9/21 10/05 10/12 10/26 11/09
116 111
227
79 0.5
5.2
92 60 152 1240.6 Nil I63.2
37 27
64
200 Nil
7.3
32 68
100
27 Nil
-
24 28
52
197 Nil 11.0
6 C
s
4
--
LOUISVILLE
HYCAR 122
9/28
__
8
4.1 Nil 1.8
10/05
--
40
12.5 Nil
4.3
10/13
_ 54
6.5 Nil
1.0
10/26
- -
45
19-8 Nil
1.8
-
LOUISVILLE HYCAR 132
EEDRICKTOVra
10/05 10/12 10/19 10/26
9/21 9/28
10/05 10/14 10/20
-__ -__
42 14 34 0 31 0 25 7 35 4
14 3
13 14
56 34 31 32 39
1.6 Nil 0.5 Nil 1.4 Nil
1.9 Nil
0.5 0.2
0.2
1.2
-
125 2 23.0
150 3 21.0
500 3 28.0
300 3 28.0
300 -
33.0
16
13 18
13 -
BFG27201
U> -si ~sl
Plant FEDRICKTOWN
-2-
Date Reported
10/26 u/03 u/09
No . Monitored
Carbon OVA Tube Total
28 0
31 0 27 0
28
31 27
Readings. ppm
High Low Average
200 7000 2000
2 32.0
k 97.0
3 58.0
No. Monitored
> 25 ppm
16 20
-
BFbCC
Pla kh AL&CP ALTC
CC HE
LB
LV pr
MWteT/WCr U/v ASSlCrK/ED
BfcNDlY MjcgoWAlR PuMfJS
On Ma*jo
Ow 0leotra
4 16
r 10
10 S'
44 23 ie
&
0Z 0 /o
JAK:cj
11/i8/7^
BFG27202
