Document 158BX0XbMn4YYV3bpO5ypaE4j

"^fe-26- f(,3 7 CENTRAL RESEARCH AND DEVELOPMENT DEPARTMENT HASKELL LABORATORY FOR TOXICOLOGY cc: ANO INDUSTRIAL MEDICINE .a* .V A 0. 3. Armitage- PPD, M-5622 W. L. Sprout y TO H. A. SMITH PPD M-5625 1a / if \ \ June 25 M* FROM: G. L. KENNEDY, OR..., fK AMMONIUM PERFLUOROOCTANOATE (ReTTl Letter HAS-GLK, 6/12/l87 .\iry ? An acceptable level for ammonium perfluoroocr anoate (C-8) in the blood of1 workers would be 0.5 p p m . This val^e nas been calculated using the average daily C-8 accumulation rate observed in new employees who were exposed to airborne c o n c e n t r a t i o n s of 0.008 mg/nr (memo, 0. G. Loschiavo to R. J . Zipfel, 7/29/82). From this data, a steady-state concentration of 0.5>i.= opm, which represents the dynamics of exposure and elimination, was estimated (Memo, T. P. Pastoor to 0. G. Loschiavo, ' 2 5 / 8 2 ) . These estimates appear consistent with most of the r e s o r t e d human data but the data base is not too extensive. In a d dition, in rat inhalation experiments, no signs of toxicity were d s i s c t e d following exposure to 1 mg/m , an atmospheric concer r r at ion corresponding to a blood level in the male rat of 12 son. Extrapolation of the data relating the concentration cf C-8 in the air to blood levels in the rat suggests that in.-slation of 0.01 mg/nr would result in blood level of approximately 1 ppm (equation is blood level = 12 "Ifair concentration). An acceptable level for community drinking w a r e : , would be 5 p p b . This value has been arrived at as follows: 1. The^AEL (8-hr TWA) is 0.01 m g / m ^ a worker b r e a t h i n g 10nr/day would take in 0.1 mg. Assume 1QC% absorption. 2. Daily ingestion by man of 2 L of water/day; 0.1 mg/2L (assume 1005 absorption) = 50 ppb (a c o n c e n t r a t i o n in water) . 000289 EID078779 3. However, community populations are not equivalent to worker populations. Therefore, factor in a 10X reduction - 5 ppb (concentration in water). This doesn't take into account the time factor (porker exposed 8 hours, not-exposed 16 hours, etc. whereas drinking water intake could be anytime during 16 hours, off 8 hours, etc.). However, the long half-life of this chemical in the blood might make this consideration less important. I hope that these suggested guidelines will be useful. Please call if you have any questions._ GLK:ma * EID078780 6 0 P!.oo'zra