Document 0gB0JXbqp2O05p1w5ZRJZ00Nm

AR226-3188 DuPont-4739 TRADE SECRET Study Title H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 5 o f 5 Laboratory Project ID: DuPont-4739 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) Author: Don A. Delker, Ph.D. Study Completed on: October 23,2001 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Work Request Number:M Service Code Number:w Sponsor Study Number: Page 1197 o f 1537 m m W tpM f S a n ili ! noortato TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX KK INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS 1198 pspamf Sanitized. Donot contain TSCA GB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Px ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: 1-0 0 mg/kg/day ANIMAL NUMBER 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 641125 641186 641052 641140 641135 641174 641107 641072 641053 641168 FINAL BODY a a a a a 760.0 539.1 614.7 565.9 507.6 745.2 593.4 567.7 724.1 543.7 541.5 579.3 539.1 638.5 576.0 THYROID GLAND 0.024 0.017 0.009 0.015 0.017 0.031 0.015 0.031 0.027 0.018 0.028 0.027 0.024 0.027 0.023 0.027 0.014 0.030 0.022 0.025 a Animals inadvertently not weighed on the day o f necropsy 1199 Banpast! g am lted Sees noeonteln t s c a c b ! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANiMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: III-O 50 mg/kg/day ANIMAL NUMBER FINAL BODY 641087 641108 641118 641128 641091 641199 641209 641163 641129 641138 641103 641181 641171 641111 641062 641156 641173 641121 641074 641191 a a a a a 612.2 536.1 528.5 567.7 575.5 658.3 600.7 667.5 535.0 564.7 618.0 603.5 616.3 616.0 580.9 THYROID GLAND 0.019 0.013 0.017 0.021 0.022 0.025 0.032 0.024 0.026 0.031 0.026 0.031 0.032 0.021 0.023 0.018 0.031 0.026 0.023 0.025 aAnimals inadvertently not weighed on the day o f necropsy 1200 Sanitized. Does not contain TSCA CBl Company H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pj. ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: V-0 250 mg/)cg/day ANIMAL NUMBER 641170 641065 641126 641058 641131 641176 641119 641075 641180 641117 641124 641082 641151 641195 641122 641184 641142 641120 641179 641164 FINAL BODY a a a a a 563.6 627.6 560.3 593.7 647.9 661.1 520.2 561.7 608.6 571.9 514.1 514.5 660.3 674.8 635.5 THYROID GLAND 0.017 0.025 0.016 0.020 0.020 0.024 0.022 0.021 0.027 0.024 0.023 0.022 0.020 0.028 0.029 0.017 0.024 0.021 0.021 0.022 Animals inadvertently not weighed on the day o f necropsy H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS Px ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: VII-0 ANIMAL NUMBER 641110 641096 641212 641068 641093 641054 641208 641193 641207 641139 641080 641078 641177 641112 641210 641152 641182 641150 641211 641145 1000 mg/kg/day FINAL BODY THYROID GLAND a a a a a 567.2 425.0 560.4 615.6 528.1 539.0 516.9 664.9 581.2 594.1 534.2 494.0 471.3 482.6 488.7 0.019 0.025 0.017 0.019 0.022 0.034 0.019 0.015 b 0.019 0.022 0.028 0.031 0.031 0.022 0.017 0.024 0.03 0.029 0.024 aAnimals inadvertently not weighed on the day o f necropsy bThyroid gland was not available. 1202 Company Sam lted. Does notconaln TSCA Cl! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: II-O ANIMAL NUMBER 641345 641236 641337 641328 641310 641324 641371 641332 641358 641389 641317 641255 641403 641388 641261 641306 641349 641346 641308 0 mg/kg/day FINAL BODY 293.4 353.9 354.4 374.2 317.2 334.7 334.8 360.2 329.5 335.4 360.7 346.8 389.8 384.5 335.2 340.0 361.9 357.6 340.5 THYROID GLAND 0.022 0.015 0.019 0.018 0.035 0.013 0.012 0.018 0.022 0.017 0.024 0.008 0.018 0.016 0.017 0.017 0.020 0.019 0.012 1203 C npf Sanitized. Does not oniata TSCCBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: IV-0 50 mg/kg/day ANIMAL NUMBER FINAL BODY 641378 641263 641297 641304 641274 641351 641272 641258 641276 641350 641376 641315 641286 641231 641338 641318 641373 641365 641348 641323 ; 373.5 323.1 350.7 339.6 377.7 329.3 308.0 376.5 404.8 335.5 342.6 366.1 340.7 318.0 322.7 340.5 396.7 349.3 397.1 346.2 THYROID GLAND 0.018 0.025 0.015 0.018 0.024 0.018 0.027 0.013 0.026 0.014 0.016 0.019 0.018 0.018 0.033 0.015 0.017 0.018 0.022 0.017 1204 gompanySanitized. Does micontain TSCAcm H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VI-0 250 mg/kg/day ANIMAL NUMBER 641271 641280 641252 641386 641277 641233 641238 641235 641392 641360 641381 641333 641239 641228 641334 641347 641367 641303 641339 641316 FINAL BODY 343.1 323.7 339.6 339.2 355.4 356.9 324.0 319.1 _a 326.7 380.4 411.0 388.2 390.7 324.0 361.0 367.3 318.0 367.5 353.8 THYROID GLAND 0.018 0.020 0.016 0.019 0.019 0.018 0.017 0.013 0.020 0.028 0.024 0.012 0.035 0.015 0.021 0.021 0.019 0.015 0.020 a Found dead on day 107; final body and thyroid weights were not taken. 1205 G w p a w ' Sanltteed. Does not contain TSCA CI H-24616: Subchronie Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP : VIII-0 1000-mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242 641284 641230 641273 641296 641248 641370 641243 641329 360.9 335.0 300.0 310.7 367.4 302.3 320.9 318.3 349.5 393.3 355.5 374.6 357.6 318.8 318.4 313.1 355.3 357.2 374.3 315.3 0.008 0.022 0.012 0.018 0.008 0.025 0.019 0.015 0.022 0.018 0.020 0.013 0.019 0.016 0.022 0.018 0.012 0.012 0.022 0.013 1206 Gwwpfflf SanSftacL m t contain TSCA OB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fj. ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: 1-1 - 0 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER 644438 644439 644440 644441 644442 644443 644444 644445 644446 644447 644448 644449 644450 644451 644452 644453 644454 644455 404.8 390.2 387.4 477.2 373.4 388.5 398.2 412.6 483.4 389.7 453.8 415.4 398.5 378.2 428.5 401.8 423.0 376.2 14.551 17.516 18.016 20.448 17.713 17.158 17.330 19.261 24.554 18.852 21.354 19.266 17.973 16.815 19.112 18.135 19.295 17.240 THYROID GLAND 0.025 0.027 0.028 0.022 0.018 0.024 0.017 0.019 0.025 0.025 0.026 0.024 0.020 0.029 0.022 0.026 0.031 0.021 PROSTATE 0.414 0.522 0.569 0.439 0.393 0.481 0.368 0.518 0.412 0.481 0.605 0.712 0.440 0.503 0.458 0.690 0.434 0.204 SEMINAL VESICLES 1.398 1.347 0.915 0.949 0.919 1.427 1.341 1.081 1.272 1.628 1.450 1.349 1.140 1.299 1.138 1.187 1.429 1.518 TESTES 3.177 3.113 3.126 3.106 3.179 3.436 3.331 2.976 3.509 3.058 3.224 3.098 3.252 2.949 3.136 3.653 3.308 3.264 EPIDIDYMIDES BRAIN 0.874 3.916a 0.727 0.752 0.830 1.068 0.802 0.745 0.887 0.735 0.869 0.984 0.760 0.837 0.875 0.870 0.828 0.798 2.007 1.890 1.905 2.003 1.924 2.019 1.770 1.970 1.965 1.992 2.034 1.811 1.816 1.822 1.957 2.106 2.031 1.972 P@@snot TOneln TSCA CBI aWeighing error; value excluded from statistical analyses. 1207 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: III-l - 50 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER THYROID GLAND PROSTATE SEMINAL VESICLES TESTES EPIDIDYMIDES BRAIN 644508 644509 644510 644511 644512 644513 644514 644515 644516 644517 644518 644519 644520 644521 644522 644523 644524 644525 468.4 19.739 429.1 19.301 459.2 22.948 481.4 20.162 403.8 . 16.488 413.7 17.892 398.1 17.696 390.5 18.126 368.7 16.666 421.3 20.338 421.4 18.949 422.1 18.865 409.3 19.878 408.8 18.913 361.2 15.891 434.3 21.120 431.8 16.240 428.6 21.168 0.027 0.027 0.024 0.036 0.022 0.018 0.024 0.025 0.021 0.019 0.027 0.018 0.014 0.015 0.020 0.026 0.028 0.018 0.396 0.506 0.499 0.631 0.413 0.348 0.838 0.568 0.370 0.592 0.561 0.498 0.455 0.499 0.449 0.475 0.525 0.560 1.126 1.192 1.323 1.348 1.269 1.286 1.098 1.147 1.044 1.152 1.439 1.318 1.070 1.171 1.204 1.443 1.080 1.091 3.225 2.995 3.063 3.442 3.233 2.970 2.998 3.182 3.179 3.546 3.327 3.181 3.308 3.230 2.979 3.391 3.550 3.166 0.900 0.768 0.835 0.981 0.806 0.757 0.819 0.838 0.832 0.823 0.826 0.796 0.747 0.818 0.796 0.886 0.683 0.785 1.955 2.023 1.966 2.081 1.896 2.026 1.980 2.018 1.963 1.958 1.936 2.021 1.976 1.987 2.048 2.036 1.964 2.030 sntpMsr Sanitized. Does not contain TSCA CB| 1208 IP H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fj. ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: V-l - 250 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER THYROID SEMINAL GLAND PROSTATE VESICLES TESTES EPIDIDYMIDES BRAIN 644577 644578 644579 644580 644581 644582 644583 644584 644585 644586 644587 644588 382.3 425.1 373.6 465.8 314.5 376.5 431.7 379.4 413.9 405.6 428.3 358.5 17.245 17.344 16.026 21.447 11.296 17.256 19.424 15.655 18.257 21.213 21.062 15.429 0.020 0.020 0.014 0.020 0.014 0.020 0.021 0.016 0.018 0.018 0.017 0.016 0.377 0.422 0.506 0.464 0.217 0.654 ' 0.525 0.462 0.461 0.274 0.532 0.409 1.100 1.372 0.893 1.825 0.370 1.498 1.314 1.097 1.130 1.158 1.349 1.008 3.575 3.518 3.219 3.786 2.679 2.989 2.995 3.260 3.367 3.469 3.266 3.342 0.886 0.850 0.790 1.013 0.570 0.795 0.884 0.805 0.911 0.708 0.784 0.791 2.013 1.984 1.942 2.164 1.679 1.745 1.900 1.928 1.984 2.062 2.056 2.029 fiWBpany Sanitized. Does net confa5' i 1209 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL FINAL. BODY AND ORGAN WEIGHTS - Fx ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: VII-1 - 1000 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER THYROID SEMINAL GLAND PROSTATE VESICLES TESTES EPIDIDYMIDES BRAIN 644625 644626 644627 644628 644629 644630 644631 644632 644633 644634 644635 644636 644637 644638 644639 644640 644641 644642 457.2 406.2 395.2 366.6 413.2 365.8 344.3 389.9 423.3 414.0 403.9 458.3 382.7 379.9 424.3 413.0 402.4 344.9 20.507 18.627 17.445 15.456 18.679 14.059 13.993 17.347 18.700 17.312 19.322 19.061 18.354 15.100 18.856 18.461 16.408 17.995 0.020 0.013 0.018 0.020 0.017 0.016 0.012 0.022 0.013 0.022 0.018 0.019 0.010 0.013 0.018 0.020 0.018 0.013 0.538 0.409 0.604 0.447 0.624 0.416 0.501 0.611 0.562 0.559 0.426 0.513 0.389 0.372 0.472 0.534 0.464 0.445 1.458 1.215 1.457 1.540 0.827 0.945 0.972 1.307 1.078 1.424 1.267 1.474 1.005 1.359 1.301 1.529 1.115 0.915 3.446 3.023 3.147 3.457 3.201 2.984 2.982 3.439 3.118 3.419 3.145 3.642 2.905 2.796 3.608 3.142 3.066 3.628 0.775 0.885 0.742 0.743 0.801 0.809 0.694 0.845 0.879 0.875 0.757 1.030 0.749 0.681 0.801 0.804 0.718 0.764 1.945 1.994 1.808 1.946 2.064 1.931 1.794 1.945 2.008 1.982 1.994 1.909 1.919 1.976 2.011 1.985 1.916 1.879 ftwap! Sanitized. Does notcontain TSCACBl 1210 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: II-l - 0 mg/kg/day ANIMAL NUMBER final' BODY LIVER 644698 644699 644700 644701 644702 644703 644704 644705 644706 644707 644708 644709 644710 644711 644712 644713 644714 644715 238.0 231.1 252.9 278.4 242.6 260.4 271.4 256.9 240.4 254.9 270.7 245.0 245.0 231.3 252.9 245.6 230.6 213.1 8.235 9.617 10.213 12.185 8.945 12.516 10.925 10.887 9.323 12.716 11.178 11.245 10.555 9.659 9.311 10.105 9.206 7.920 THYROID GLAND 0.019 0.022 0.020 0.016 0.019 0.023 0.018 0.015 0.018 0.016 0.019 0.022 0.021 0.026 0.016 0.021 0.019 0.020 UTERUS 0.333 0.666 0.455 0.428 0.408 0.698 0.457 0.362 0.620 0.363 0.384 0.365 0.399 0.440 0.448 0.888 0.458 0.347 BRAIN 1.809 1.809 1.815 1.778 1.852 1.839 1.750 1.819 1.868 1.836 1.690 1.900 1.790 1.720 1.763 1.879 1.778 1.794 1211 ompanjr s Hked. Does not contain TSOA C3I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fj. ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: IV-1 - 50 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER THYROID GLAND UTERUS BRAIN 644770 644771 644772 644773 644774 644775 644776 644777 644778 644779 644780 644781 644782 644783 644784 644785 644786 644787 249.7 225.9 251.0 285.1 249.0 231.3 241.4 235.2 222.1 216.1 269.1 257.1 206.5 272.6 255.4 235.3 302.8 273.1 8.989 8.952 11.176 12.954 10.282 10.327 10.477 9.959 9.893 9.549 10.664 11.256 8.494 12.379 11.791 9.073 11.129 13.212 0.023 0.023 0.018 0.020 0.021 0.016 0.026 0.015 0.012 0.015 0.020 0.016 0.020 0.017 0.018 0.016 0.020 0.018 0.824 0.867 0.440 0.630 0.465 0.587 0.585 0.495 0.482 0.390 1.051 0.603 0.388 0.417 0.417 0.498 0.408 0.548 . 1.735 1.770 1.829 1.897 1.828 1.938 1.955 1.866 1.776 1.699 1.889 1.877 1.803 1.818 1.868 1.831 1.784 1.889 1212 .Companf Sanitized, Does not contain TSCA G81 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VI-1 - 250 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER 644842 644843 644844 644845 644846 644847 644848 644849 644850 644851 644852 644853 211.4 283.7 251.3 234.9 238.5 285.8 216.3 243.7 312.7 233.5 287.7 215.3 7.386 12.143 10.140 9.002 9.330 12.352 9.638 10.673 13.393 9.804 13.499 7.588 THYROID GLAND 0.018 0.015 0.012 0.015 0.021 0.018 0.008 0.016 0.020 0.015 0.013 0.017 UTERUS 0.418 0.744 0.565 0.444 0.475 0.375 0.403 0.496 0.402 0.748 0.512 0.563 BRAIN 1.813 1.940 11.975* 1.802 1.698 1.969 1.455 1.827 1.874 1.746 1.951 1.837 a Weighing error; value excluded from statistical analyses. 1213 Cesnpwy Sanitized. Does not contain TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VIII-1 - 1000 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER 644889 644890 644891 644892 644893 644894 644895 644896 644897 644898 644899 644900 644901 644902 644903 644904 644905 644906 258.0 203.9 247.9 228.0 228.6 210.0 249.7 248.5 245.0 257.8 241.6 265.0 259.8 229.4 242.5 238.1 248.5 218.9 10.240 8.026 11.333 9.467 9.800 7.878 11.905 9.072 10.882 11.043 10.214 10.565 11.569 9.097 10.381 10.700 8.467 8.516 THYROID GLAND 0.015 0.007 _a 0.013 0.010 0.013 0.009 0.012 0.010 0.010 0.017 0.010 0.011 0.013 0.006 0.008 0.011 0.007 UTERUS 0.388 0.356 0.398 0.440 0.514 0.737 0.372 0.440 0.532 0.481 0.291 0.429 0.448 0.321 0.341 0.484 0.407 0.413 BRAIN 1.785 1.740 1.784 1.906 1.816 1.771 1.802 1.660 1.834 1.771 1.786 1.794 1.835 1.810 1.769 1.837 1.581 1.813 aThyroid gland inadvertently not weighed. 1214 Company Sanitized. Does not contain TSCA CSI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX LL INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS FOR Pi ADULTS 1215 Cmnpmf Sanitized. Does not confab "SCft CBF H-24616: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS KEY TO APPENDIX ABBREVIATIONS : FD - FOUND DEAD , SD - SACRIFICED BY DESIGN LESION GRADING: Histopathological changes are described according to their morphologic character, distribution and severity. The distribution (extent of tissue involvement) is indicated, where appropriate, by modifiers such as focal, multifocal, diffuse, unilateral, bilateral, etc. A severity score, if appropriate, is also assigned as follows: MINIMAL: The amount of change present barely exceeds that which is considered to be within normal limits. MILD: In general, the lesion is easily identified but of limited severity. The lesion probably does not produce any functional impairment. MODERATE: The lesion is prominent but there is significant potential for increased severity. Limited tissue or organ dysfunction is possible. - SEVERE: The degree of change is either as complete as considered possible or great enough in intensity or extent to expect significant tissue or organ dysfunction. COMMENT : Grades minimal through severe represent progressive involvement/severity along a continuum with minimal lesions being the least severe and severe lesions being the most severe. While the grades refer to the morphological characteristics of lesions, they also indicate their relative biological significance. Gross observations listing multiple masses for a tissue are distinguished with letters (i.e., a, b, c, d, etc.). 1216 rapany Sanitized. Does not eontafn YSC CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS, MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641052 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA C8I 1217 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641053 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ComPany Sanitized. Does not contain TSCA CBI 1218 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641060 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF'AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1219 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641072 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does nt contain TSCA CBS 1220 m H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641079 DAYS ON TEST: 108 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VESICLES, TESTIS COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Does nf contain TSCA CS 1221 li H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641100 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE .empanjSanitized. Does no*contain -TSCCB 1222 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day V DuPont-4739 ANIMAL #: 641106 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ikw tfSiA U|B|UOOJOU S@@0 1223 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641107 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1224 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day m DuPont-4739 ANIMAL #: 641114 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE m I IDoesm confab TSCA C3i 1225 if H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641125 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does noconfalo TSCACBS 1226 fP H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641135 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions) MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE S tam p s SanBbed. Does notcontain TSCACBS 1227 I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641140 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SanfUzed. Boss notcontain TSC CB 1228 v _ ,.' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL # : 641158 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lsions): MICROSCOPIC OBSERVATIONS : NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES : NONE 1229 I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641168 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE LDoes not eonten TSC CB 1230 r , (i? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641174 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE iom seaa 'psaHjUBgitoBAHggi 1231 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641175 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VESICLES, TESTIS COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE TSCACBI 1232 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641186 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE wtspanfSanitized. @@$notcontain TSCACBI 1233 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641188 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE &ipanjf Sanitized. Does netcontain TSCACBS 1234 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641204 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE is o W3S i ujBiuoojshj ssoq "poefflueg Am m Q 1235 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day DuPont-4739 ANIMAL #: 641217 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SanRfeed. Oses no?containTSCAC0 1236 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641062 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized Oses notcontain TSCACBI 1237 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641074 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE C0 1 1. Dees noisoniate T8CA CBt 1238 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641087 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE gM fflpaf Sanitized. Bees no eontaln TSC CB 1239 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641091 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VESICLES, TESTIS COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1240 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day ANIMAL #: 641103 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: SKIN MICROSCOPIC CORRELATE (selected lesions): - ALOPECIA, VENTRAL, NECK; ULCERATED MICROSCOPIC OBSERVATIONS: OTHER - SKIN: INFLAMMATION/ULCER, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: SEMINAL VESICLES, TESTES COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE P011* Sanitized, Does notcontain TSCACB 1241 7_ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________ _____ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641108 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Similized. Does notcontain TSCACBt 1242 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641111 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Boas mi containTSCA 1243 I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641118 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE BwnpMf'Sanitized. Does noteontam TSCACP? 1244 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641121 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does ns! confab tsca CR 1245 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641128 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE S&mpmf Sanitized. Dees not contain TSCACBi 1246 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641129 DAYS ON TEST: 108 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VESICLES, TESTIS COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 9M pj Santfzed. Does no! eerstatn TSCA CBI 1247 b -' I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day ANIMAL #: 641138 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Cwwpwy Sanitized, Does notcontain TSCACBi 1248 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641156 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1249 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day ________ DuPont-4739 ANIMAL #: 641163 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ompanySanitized. Does no! contain TSCACBS 1250 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641171 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE prnm oe ssm m Q Q 1251 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641173 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641181 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Doe nfen'***'" TSf* 1253 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641191 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanfifced. Does net entale TSCA CBI 1254 vj W H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641199 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Bees net contain TSCA OBI 1255 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 50 mg/kg/day DuPont-4739 ANIMAL #: 641209 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE P&mpeny Sanitized. Dobs not contain TSCA CBI 1256 if H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641058 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions) MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VESICLES, TESTIS COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 33 c 1 I S I 1257 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641065 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VESICLES, TESTIS COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641075 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Bees net contain TSCA CBS 1259 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641082 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: SEMINAL VESICLES, TESTES COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . Does not contain T Cil 1260 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641117 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 183 VOS! uiBiuoopu ssofl "pa^ipoeg 1261 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641119 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Does notcontain TSCACBI 1262 ci H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL # : 641120 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Does not contain TSCACBS 1263 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641122 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE jSoHlfiy Sanifeed. Does no? eorsSan TSCA CRI 1264 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641124 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: PROSTATE - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIDES, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE OSA sepe p u s* 'p&gpejg 1265 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day 3 DuPont-4739 ANIMAL #: 641126 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: VESICLES, TESTIS COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ferapawfSanitized. Does notcontain TSCAcr 1266 I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641131 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does not contain TSCA CB1 1267 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641142 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: SEMINAL VESICLES, TESTES COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1268 tf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day i DuPont-4739 ANIMAL #: 641151 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does no!oonta!n 7 SCACJ 1269 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641164 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Dees notcontain TSCACBI 1270 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641170 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ipaftySanHteed. Doesno?contain TSCAC 1271 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641176 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE anpany SanRteed. Does nocantata TSCA cbj 1272 if H-24616: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641179 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1273 I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641180 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 3 Q $A ajigposp u S80Q "p^|ugg AadMugj 1274 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P* ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641184 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CdTipsfSanMzed. Does no!contain TSCACBI 1275 v_- H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 250 mg/kg/day DuPont-4739 ANIMAL #: 641195 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: SEMINAL VESICLES, TESTES COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1276 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641054 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Dees nocontain TSCA O __________________________________________________________ S 1277 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641068 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641078 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: SEMINAL VESICLES, TESTES COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 8 1279 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641080 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE wpanf Sanitised, Uses not contain TSCCtt 1280 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641093 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: EPIDIDYMIDES TESTES MICROSCOPIC CORRELATE (selected lesions): - DISCOLORATION, YELLOW, RIGHT; HEAD - SOFT, PALE, RIGHT MICROSCOPIC OBSERVATIONS: EPIDIDYMIS TESTIS - GRANULOMA, SPERM, MILD - OLIGOSPERMIA/GERM CELL DEBRIS, SEVERE - DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, SEVERE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, PROSTATE, SEMINAL VESICLES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE esm paf SanRfeed. Boss no!contain TSCACB! 1281 P H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641096 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE K VOSJ. u|B|UC J0 1282 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641110 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641112 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1284 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641139 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1285 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641145 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Does netcontain TSCCEI 1286 to H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641150 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . Does not eontain TSC CBI 1287 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641152 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanftfesd. Does no?containTSCCBI 1288 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641177 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Oompanf Sanitized. Does not contain TSCA CBS 1289 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641182 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SwapaafSanfHzedLDoes notcontainTSCACB! 1290 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641193 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE VW&li uj*uuy 40 ssaog pazmueg 1291 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641207 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE tfesspMf Sanltesd Sees no? contain TSCA CBf- 1292 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641208 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE m Does no? confato TSCA CBS 1293 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641210 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: LUNGS MICROSCOPIC CORRELATE (selected lesions): DISCOLORATION, TAN, LEFT; 5MM DIA MICROSCOPIC OBSERVATIONS : OTHER LUNGS: FOREIGN MATERIAL, MINIMAL LUNGS: INFLAMMATION, GRANULOMATOUS, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: SEMINAL VESICLES, TESTES COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE. FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does not coniato T3CA i 1294 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641211 DAYS ON TEST: 110 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE C08*PF Does noteonfafa TSCA 1295 __ , H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg/day DuPont-4739 ANIMAL #: 641212 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1296 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641236 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641255 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641261 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does no!eonfafn TSCA CB 1299  H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations l DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641289 DAYS ON TEST: 116 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1300 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641306 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1301 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P-l ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641308 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641310 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ,@mpaisf Sanitized. Does not contain TSA CB1 1303 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641317 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ftnpany Sanitized Does notcontain TSCACBS 1304 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641324 DAYS ON TEST: 116 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Dees not contain TSCA CBI 1305 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641328 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations i DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641332 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . Dees no!contain TSCCBI 1307 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 6 4 1337 DAYS ON TEST: 11 6 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sosnpatt Sanfflzed. Dees netcontain TSCACB! 1308 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641345 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE fflipanf Sanitized. Does noeon!a?n TSCACB! 1309 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641346 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Etoes noteortaln TSCACBS 1310 I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641349 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1311 if! \ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641358 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE w*Hked. Does no*contain TSCAC B I 1312 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641371 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641388 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE I THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE I THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE m SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE 2 SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN 8 INCIDENCE TABLES: NONE 1 I I a 1314 I I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641389 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does notcontain TSCACBB 1315 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 641403 DAYS ON TEST: 116 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641231 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: VAGINA MICROSCOPIC CORRELATE (selected lesions): - DISCOLORATION, TAN, RAISED; 3MM DIA MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE I THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641258 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE .Wpstn^ Sanitized. Boss not contain TSCA CBf 1318 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641263 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE .CompanySanitized. Does not contain TSC.A OB* 1319 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi. ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641272 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE GompmySanitized* Does notcontain TSCA 1320 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641274 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE empany Sanitized. Dees no? contain rg e > J 1321 H-24616: Subchionic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641276 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACBS 1322 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641286 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ompanySanitized. Doesnotcontain TSCACBl 1323 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641297 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CompanySanitized. Does not contain TSCACBI 1324 w H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641304 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 193 V3SJ, Ujejiioo}ou 1325 H -24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641315 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641318 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641323 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Miparaf Sw lfeed. Does not contain TSCA CBS 1328 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641338 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE .pasySanitized, Does no!contain TSCACBS 1329 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641348 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does contain T8CA CBS 1330 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641350 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1331 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641351 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1Does notoa!rs TSCACi! 1332 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641365 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE gempmf Sanitized. Dees not contain TSCA CSl 1333 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641373 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: SKIN MICROSCOPIC CORRELATE (selected lesions): - ALOPECIA, MODERATE, VENTRAL BODY MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE C*V,mjr oss not contain TSCACBi 1334 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641376 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE HI C8 O S 3 1335 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: IV-0 DOSE: 50 mg/kg/day ANIMAL #: 641378 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CSI 1336 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641228 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE a 1Does nof eonfaln TSCA CBS 1337 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641233 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE &tfmi py ig fiiip g g Anduna 1338 P H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641235 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1339 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641238 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641239 DAYS ON TEST: 116 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE v o s i usemos lou seoQ "pszppgg meumQ 1341 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641252 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized Does mi contain TSCA CBS 1342 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641271 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CompanySanitized. Dees no!contain TSCABI 1343 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641277 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanfflzed. Does not contain rSCA C8f 1344 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641280 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CompanySanitized. Does notcontain TSCACBS 1345 IP H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations f DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641303 DAYS ON TEST: 116 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Dees not contain TSCA CB! 1346 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641316 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE I Does noicontain TSCACB! 1347 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641333 DAYS ON TEST: 113 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Does noi fr.funltsh 1 1348 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641334 DAYS ON TEST: 124 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCpPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Swtlfeed, Dopn contain TSCA CB 1349 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641339 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1350 1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641347 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Bee noi sorta! T8CACBl 1351 'O H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641360 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE pOZJIfUBS 3 o 1352 m H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641367 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Does not contain TSCA C S I 1353 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641381 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: OVARIES - ATROPHY, MILD THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 'Gmpmy Sanitized. Does not contain TSCACBI 1354 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641386 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CoBmpairsjSanitized Does notcontain TSCACB1 1355 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 250 mg/kg/day ANIMAL #: 641392 DAYS ON TEST: 107 MODE OF DEATH: FD GROSS OBSERVATIONS: URINARY BLADDER KIDNEYS VAGINA MICROSCOPIC CORRELATE - DILATATION, SEVERE; THICK TAN FLUID FILLED - CALCULUS, MODERATE, BILATERAL, PELVIS - FLUID, GREEN, GELATINOUS (selected lesions): I3a MICROSCOPIC OBSERVATIONS: OTHER - HYDRONEPHROSIS, BILATERAL, MILD - KIDNEYS: INFLAMMATION, ACUTE, SEVERE - URINARY BLADDER: INFLAMMATION, SUBACUTE/CHRONIC, MILD h 8 THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: VAGINA THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE oauu "ps^Mioeg mchuoQ 3 ? I3 SI>a i > ,,1 1356 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ___________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641230 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE fi J8 l VQan, iSifuisQ ju u 1357 ||||f i H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pa ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641242 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT.COUNTED IN INCIDENCE TABLES: NONE i. Does notcontain TSCACBf 1358 L'~- H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641243 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Smi a cn 53 O 2. O S o 1359 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641246 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SmprnuySanitized. DoesnoScontain TSCACB! 1360 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641248 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE omparsj Sanfffed. Oses not confafn TSCACBI 1361 _ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641254 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): > MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Dess not contain TSCACSf 1362 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641265 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1363 9 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641273 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE confalo TSCA CBf N a oa 3 Q 1364 iljjli r H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641284 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE S a n itiz e d , Does not confa! Te 1365 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641296 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day anySanded. Doesnotcontain TSCACB? ANIMAL #: 641307 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE I SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 3$ 3 S5s' 1 1367 w H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641320 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE r 3 % * Si 8:- S' rI.; r .sain T B C A OBJ 1368 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641329 DAYS ON TEST: 117 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ! mt contain TSC CBS 1369 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641343 DAYS ON TEST: 116 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641353 DAYS ON TEST: 114 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Does not contain TSCAC8I 1371 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641368 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE i_. H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641370 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE anltfee& Dess not contain TSCA CB1 1373 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641393 DAYS ON TEST: 115 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1374 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641401 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE i $ l a ce O > O 2 1375 v_ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg/day ANIMAL #: 641402 DAYS ON TEST: 116 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SempeRgSanitized. Doss noteonteSn TSCACBf 1376 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX MM INDIVIDUAL ANIMAL GROSS OBSERVATIONS FOR Fi PUPS TSCCBS 1377 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. PUPS DAM GROUP: II-O DOSE: 0 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 641310 F 643825 -21 FD 643826 -21 FD 641306 M 643805 -21 FD F 643827 -21 FD 641349 F 643828 -21 FD XXX= JLH STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED XXX= JLH STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED XXX= SWR STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED XXX= JLH STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED XXX= SWR STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED DuPont-4739 HPflf Sanitized. Does notcontain SCA C83 1378 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F 1 PUPS DAM GROUP: IV-0 DOSE: 50 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 641351 F 643830 -21 FD XXX= JLH STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED DuPont-4739 Does not contain TSCA CB1 1379 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx PUPS DAM GROUP: VI-0 DOSE: 250 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 641271 F 643835 -21 FD 641238 F 643836 -21 FD 643837 -7 FD XXX= JLH STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED XXX= JLH STOMACH T NO MILK SPOT LUNGS - NOT EXPANDED PERITONEAL CAVITY - FLUID, CLEAR, MODERATE DuPont-4739 w H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx PUPS DAM GROUP: VIII-0 DOSE: 1000 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE ========= OBSERVATIONS 641393 M 643823 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 641353 M 643820 -21 FD XXX=SWR STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 641296 M 643821 -21 FD 643822 -21 FD XXX= SWR STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED XXX= SWR WHOLE BODY - AUTOLYSIS DuPont-4739 PMVMUfSaiMzed. Dees not contai T8C5A<5l 1381 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX NN INDIVIDUAL ANIMAL GROSS OBSERVATIONS FOR Fj WEANLINGS 1382 S o n p o f Sanitee, Does mA mtaln TSG CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS EXPLANATORY NOTES Note Day o f weaning = Test Day 1. 1383 @mpw% Sanitized. Dees no?confato TSCAQB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS MALE RATS GROUP: 1-1 DOSE: 0 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE 644456 1 SP 644457 1 SP 644458 1 SP 644459 1 SP 644460 1 SP 644461 1 SP 644462 1 SP 644463 1 SP 644464 1 SP 644465 1 SP 644466 1 SP 644467 1 SP 644468 1 SP 644469 1 SP 644470 1 SP 644471 1 SP 644472 1 SP 644473 1 SP 644474 1 SP 644475 1 SP 644476 1 SP 644477 1 SP 644478 1 SP 644479 1 SP 644480 1 SP OBSERVATIONS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-4739 1384 Company SanHfeed. Does noeonialn TSCA OBf H -24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS MALE RATS GROUP: 1-1 DOSE: 0 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE 644481 1 SP 644482 1 SP 644483 1 SP 644484 1 SP 644485 1 SP 644486 1 SP 644487 1 SP 644488 1 SP 644489 1 SP 644490 1 SP 644491 1 SP 644492 1 SP 644493 1 SP 644494 1 SP 644495 1 SP 644496 1 SP 644497 1 SP 644498 1 SP 644499 1 SP 644500 1 SP 644501 1 SP 644502 1 SP 644503 1 SP 644504 1 SP 644505 1 SP 644506 1 SP 644507 1 SP OBSERVATIONS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-4739 1385 t a p i f SamlfeedL Does no! contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS MALE RATS GROUP: III-l DOSE: 50 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS 644526 644527 1 SP NO ABNORMALITIES DETECTED * 1 SP NO ABNORMALITIES DETECTED 644528 1 SP NO ABNORMALITIES DETECTED 644529 1 SP NO ABNORMALITIES DETECTED 644530 1 SP NO ABNORMALITIES DETECTED 644531 644532 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644533 644534 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644535 1 SP NO ABNORMALITIES DETECTED 644536 1 SP NO ABNORMALITIES DETECTED 644537 644538 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644539 1 SP NO ABNORMALITIES DETECTED 644540 1 SP NO ABNORMALITIES DETECTED 644541 644542 644543 644544 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644545 644546 644547 644548 644549 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED a NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644550 1 SP NO ABNORMALITIES DETECTED 644551 644552 1 SP 1 SP NO ABNORMALITIES DETECTED a a Due to error, data were not recorded. 1386 DuPont-4739 ITWais* H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS MALE RATS GROUP: III-l DOSE: 50 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE 644553 1 SP 644554 1 SP 644555 1 SP 644556 1 SP 644557 1 SP 644558 1 SP 644559 1 SP 644560 1 SP 644561 1 SP 644562 1 SP 644563 1 SP 644564 1 SP 644565 1 SP 644566 1 SP 644567 1 SP 644568 1 SP 644569 1 SP 644570 1 SP 644571 1 SP 644572 1 SP 644573 1 SP 644574 1 SP 644575 1 SP 644576 1 SP OBSERVATIONS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-4739 1387 8 * P 0 y S a n fc e i. D o e s not contain TSCA C B I H -24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS MALE RATS GROUP: V-l DOSE: 250 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE 644589 1 SP 644590 1 SP 644591 1 SP 644592 1 SP 644593 1 SP 644594 1 SP 644595 1 SP 644596 1 SP 644597 1 SP 644598 1 SP 644599 1 SP 644600 1 SP 644601 1 SP 644602 1 SP 644603 1 SP OBSERVATIONS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-4739 1388 Q o n pn r M lh e d . D@ <***'*>TSCA CB1 orapanySanitized. Does - H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS MALE RATS GROUP: V-l DOSE: 250 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE 644604 1 SP 644605 1 SP 644606 1 SP 644607 1 SP 644608 1 SP 644609 1 SP 644610 1 SP 644611 1 SP 644612 1 SP 644613 1 SP 644614 1 SP 644615 1 SP 644616 1 SP 644617 1 SP 644618 1 SP 644619 1 SP 644620 1 SP 644621 1 SP 644622 1 SP 644623 1 SP 644624 1 SP OBSERVATIONS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED a NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-4739 a Due to error, data were not recorded. 1389 Company Sanitized. Does noI contain TSCA CBI ^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS MALE RATS GROUP: VII-1 DOSE: 1000 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS 644643 1 SP NO ABNORMALITIES DETECTED 644644 1 SP NO ABNORMALITIES DETECTED 644645 1 SP NO ABNORMALITIES DETECTED 644646 1 SP NO ABNORMALITIES DETECTED 644647 1 SP NO ABNORMALITIES DETECTED 644648 1 SP NO ABNORMALITIES DETECTED 644649 1 SP NO ABNORMALITIES DETECTED 644650 1 SP NO ABNORMALITIES DETECTED 644651 1 SP NO ABNORMALITIES DETECTED 644652 1 SP NO ABNORMALITIES DETECTED 644653 1 SP NO ABNORMALITIES DETECTED 644654 1 SP NO ABNORMALITIES DETECTED 644655 1 SP NO ABNORMALITIES DETECTED 644656 1 SP NO ABNORMALITIES DETECTED 644657 1 SP NO ABNORMALITIES DETECTED 644658 1 SP NO ABNORMALITIES DETECTED 644659 1 SP NO ABNORMALITIES DETECTED 644660 1 SP NO ABNORMALITIES DETECTED 644661 1 SP NO ABNORMALITIES DETECTED 644662 1 SP NO ABNORMALITIES DETECTED 644663 1 SP NO ABNORMALITIES DETECTED 644664 1 SP NO ABNORMALITIES DETECTED 644665 1 SP NO ABNORMALITIES DETECTED 644666 1 SP NO ABNORMALITIES DETECTED 644667 1 SP NO ABNORMALITIES DETECTED DuPont-4739 i 1390 "J' ^ W n T S C A C ^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS MALE RATS GROUP: VII-1 DOSE: 1000 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS 644668 1 SP NO ABNORMALITIES DETECTED 644669 1 SP NO ABNORMALITIES DETECTED 644670 1 SP NO ABNORMALITIES DETECTED 644671 1 SP NO ABNORMALITIES DETECTED 644672 1 SP NO ABNORMALITIES DETECTED 644673 1 SP NO ABNORMALITIES DETECTED 644674 1 . SP NO ABNORMALITIES DETECTED 644675 1 SP NO ABNORMALITIES DETECTED 644676 1 SP NO ABNORMALITIES DETECTED 644677 1 SP NO ABNORMALITIES DETECTED 644678 1 SP NO ABNORMALITIES DETECTED 644679 1 SP NO ABNORMALITIES DETECTED 644680 1 SP NO ABNORMALITIES DETECTED 644681 1 SP NO ABNORMALITIES DETECTED 644682 1 SP NO ABNORMALITIES DETECTED 644683 1 SP NO ABNORMALITIES DETECTED 644684 1 SP NO ABNORMALITIES DETECTED 644685 644686 1 SP 1 SP NO ABNORMALITIES DETECTED a 644687 1 SP NO ABNORMALITIES DETECTED 644688 1 SP NO ABNORMALITIES DETECTED DuPont-4739 3 Due to error, data were not recorded. 1391 SM teed. Bes rS eemtata TSC CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS MALE RATS GROUP: VII-1 DOSE: 1000 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE 644689 1 SP 644690 1 SP 644691 1 SP 644692 1 SP 644693 1 SP 644694 1 SP 644695 1 SP 644696 1 SP 644697 1 SP OBSERVATIONS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-4739 1392 S&mpmtg SwSfced. O m s notonfalrs TSCACB1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS FEMALE RATS GROUP: II-l DOSE: 0 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS 644716 1 SP ,NO ABNORMALITIES DETECTED 644717 1 SP NO ABNORMALITIES DETECTED 644718 1 SP NO ABNORMALITIES DETECTED 644719 1 SP NO ABNORMALITIES DETECTED 644720 1 SP NO ABNORMALITIES DETECTED 644721 1 SP NO ABNORMALITIES DETECTED 644722 1 SP KIDNEYS - DILATATION, MODERATE, RIGHT, PELVIS 644723 644724 644725 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644726 1 SP NO ABNORMALITIES DETECTED 644727 1 SP NO ABNORMALITIES DETECTED 644728 1 SP NO ABNORMALITIES DETECTED 644729 1 SP NO ABNORMALITIES DETECTED 644730 1 SP NO ABNORMALITIES DETECTED 644731 644732 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644733 1 SP NO ABNORMALITIES DETECTED 644734 1 SP NO ABNORMALITIES DETECTED 644735 1 SP NO ABNORMALITIES DETECTED 644736 1 SP NO ABNORMALITIES DETECTED 644737 1 SP NO ABNORMALITIES DETECTED 644738 1 SP NO ABNORMALITIES DETECTED 644739 1 SP NO ABNORMALITIES DETECTED 644740 1 SP NO ABNORMALITIES DETECTED DuPont-4739 1393 IBm PWF SanRbed. Does noi owfalri TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - WEANLINGS FEMALE RATS GROUP: II-l DOSE: 0 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE 644741 1 SP 644742 1 SP 644743 1 SP 644744 1 SP 644745 1 SP 644746 1 SP 644747 1 SP 644748 1 SP 644749 1 SP 644750 1 SP 644751 1 SP 644752 1 SP 644753 1 SP 644754 1 SP 644755 1 SP 644756 1 SP 644757 1 SP 644758 1 SP 644759 1 SP 644760 1 SP 644761 1 SP OBSERVATIONS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED a NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-4739 a Due to error, data were not recorded. 1394 Company SanRfeed, Does no? contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS FEMALE RATS GROUP: II-l DOSE: 0 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE 644762 1 SP 644763 1 SP 644764 1 SP 644765 1 SP 644766 1 SP 644767 1 SP 644768 1 SP 644769 1 SP OBSERVATIONS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-4739 HOf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS GROUP: IV-1 DOSE: 50 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS 644788 1 SP NO ABNORMALITIES DETECTED 644789 1 SP NO ABNORMALITIES DETECTED 644790 1 SP NO ABNORMALITIES DETECTED 644791 1 SP NO ABNORMALITIES DETECTED 644792 1 SP NO ABNORMALITIES DETECTED 644793 644794 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644795 1 SP NO ABNORMALITIES DETECTED 644796 644797 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644798 1 SP NO ABNORMALITIES DETECTED 644799 644800 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644801 1 SP NO ABNORMALITIES DETECTED 644802 ' 1 SP NO ABNORMALITIES DETECTED 644803 1 SP NO ABNORMALITIES DETECTED 644804 1 SP NO ABNORMALITIES DETECTED 644805 1 SP NO ABNORMALITIES DETECTED 644806 1 SP NO ABNORMALITIES DETECTED 644807 1 SP NO ABNORMALITIES DETECTED 644808 1 SP NO ABNORMALITIES DETECTED 644809 1 SP NO ABNORMALITIES DETECTED 644810 1 SP NO ABNORMALITIES DETECTED 644811 1 SP NO ABNORMALITIES DETECTED 644812 1 SP NO ABNORMALITIES DETECTED DuPont-4739 1396 wm S m te d , Bros not contain TSC CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS FEMALE RATS GROUP: IV-1 DOSE: 50 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS 644813 1 SP NO ABNORMALITIES DETECTED 644814 644815 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644816 1 SP NO ABNORMALITIES DETECTED 644817 1 SP NO ABNORMALITIES DETECTED 644818 1 SP NO ABNORMALITIES DETECTED 644819 1 SP NO ABNORMALITIES DETECTED 644820 1 SP NO ABNORMALITIES DETECTED 644821 1 SP NO ABNORMALITIES DETECTED 644822 1 SP NO ABNORMALITIES DETECTED 644823 644824 644825 644826 644827 644828 644829 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 644830 644831 644832 644833 644834 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-4739 1397 suparnf m I W . Bw not contain TSCAcbi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS GROUP: IV-1 DOSE: 50 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS 644835 1 SP NO ABNORMALITIES DETECTED 644836 1 SP NO ABNORMALITIES DETECTED 644837 1 SP NO ABNORMALITIES DETECTED 644838 1 SP NO ABNORMALITIES DETECTED 644839 1 SP NO ABNORMALITIES DETECTED 644840 1 SP NO ABNORMALITIES DETECTED 644841 1 SP NO ABNORMALITIES DETECTED DuPont-4739 1398 feMpMSf Boss not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS GROUP: VI-1 DOSE: 250 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS 644854 1 SP NO ABNORMALITIES DETECTED 644855 1 SP NO ABNORMALITIES DETECTED 644856 1 SP NO ABNORMALITIES DETECTED 644857 1 SP LUNGS - DEFORMITY, IRREGULAR, LEFT 644858 1 SP NO ABNORMALITIES DETECTED 644859 1 SP NO ABNORMALITIES DETECTED 644860 1 SP NO ABNORMALITIES DETECTED 644861 1 SP NO ABNORMALITIES DETECTED 644862 1 SP NO ABNORMALITIES DETECTED 644863 1 SP NO ABNORMALITIES DETECTED 644864 1 SP NO ABNORMALITIES DETECTED 644865 1 SP NO ABNORMALITIES DETECTED 644866 1 SP NO ABNORMALITIES DETECTED 644867 1 SP NO ABNORMALITIES DETECTED 644868 1 SP NO ABNORMALITIES DETECTED 644869 1 SP NO ABNORMALITIES DETECTED 644870 1 SP NO ABNORMALITIES DETECTED 644871 1 SP NO ABNORMALITIES DETECTED 644872 1 SP NO ABNORMALITIES DETECTED 644873 1 SP NO ABNORMALITIES DETECTED 644874 1 SP NO ABNORMALITIES DETECTED 644875 1 SP NO ABNORMALITIES DETECTED 644876 1 SP NO ABNORMALITIES DETECTED 644877 1 SP NO ABNORMALITIES DETECTED 644878 1 SP NO ABNORMALITIES DETECTED 644879 1 SP NO ABNORMALITIES DETECTED 644880 1 SP NO ABNORMALITIES DETECTED 644881 1 SP NO ABNORMALITIES DETECTED DuPont-4739 1399 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS FEMALE RATS GROUP: VI-1 DOSE: 250 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE 644882 1 SP 644883 1 SP 644884 1 SP 644885 1 SP 644886 1 SP 644887 1 SP 644888 1 SP OBSERVATIONS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-4739 1400 0*pa?if SanSffeed. Does no? eort?an TSCACBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS FEMALE RATS GROUP: VIII-1 DOSE: 1000 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS 644907 1 SP NO ABNORMALITIES DETECTED 644908 1 SP NO ABNORMALITIES DETECTED 644909 1 SP NO ABNORMALITIES DETECTED 644910 1 SP NO ABNORMALITIES DETECTED 644911 1 SP NO ABNORMALITIES DETECTED 644912 1 SP NO ABNORMALITIES DETECTED 644913 1 SP NO ABNORMALITIES DETECTED 644914 1 SP NO ABNORMALITIES DETECTED 644915 1 SP NO ABNORMALITIES DETECTED 644916 1 SP NO ABNORMALITIES DETECTED 644917 1 SP NO ABNORMALITIES DETECTED 644918 1 SP NO ABNORMALITIES DETECTED 644919 1 SP NO ABNORMALITIES DETECTED 644920 1 SP NO ABNORMALITIES DETECTED 644921 - 1 SP NO ABNORMALITIES DETECTED 644922 1 SP NO ABNORMALITIES DETECTED 644923 1 SP NO ABNORMALITIES DETECTED 644924 1 SP NO ABNORMALITIES DETECTED 644925 1 SP NO ABNORMALITIES DETECTED 644926 1 SP NO ABNORMALITIES DETECTED 644927 1 SP NO ABNORMALITIES DETECTED 644928 1 SP NO ABNORMALITIES DETECTED 644929 1 SP NO ABNORMALITIES DETECTED 644930 1 SP NO ABNORMALITIES DETECTED 644931 1 SP NO ABNORMALITIES DETECTED CompanySanlOzsdLDoes sot contain tSCli&Wk 1401 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj WEANLINGS FEMALE RATS GROUP: VIII-1 DOSE: 1000 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS 644932 1 SP NO ABNORMALITIES DETECTED 644933 1 SP NO ABNORMALITIES DETECTED 644934 1 SP NO ABNORMALITIES DETECTED 644935 644936 644937 644938 644939 644940 644941 644942 644943 644944 644945 644946 644947 644948 644949 644950 644951 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1- SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-4739 1402 w pany Sanfteed. 0es n@eontaln TSG CBf H -24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS GROUP: VIII-1 DOSE: 1000 mg/kg/day ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS 644952 1 SP _NO ABNORMALITIES DETECTED 644953 1 SP NO ABNORMALITIES DETECTED 644954 1 SP NO ABNORMALITIES DETECTED 644955 1 SP NO ABNORMALITIES DETECTED 644956 1 SP NO ABNORMALITIES DETECTED 644957 1 SP NO ABNORMALITIES DETECTED DuPont-4739 1403 Company Sanitized. Does to! contain TSCA C8I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX OO INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS FOR Fi ADULTS 1404 ^ p a n y Sanitized. Bees not contain TSCA Cftf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS KEY TO APPENDIX NOTE: Day of weaning = Test Day 1. ABBREVIATIONS : FD - FOUND DEAD SD - SACRIFICED BY DESIGN LESION GRADING: Histopathological changes are described according to their morphologic character, distribution and severity. The distribution (extent of tissue involvement) is indicated, where appropriate, by modifiers such as focal, multifocal, diffuse, unilateral, bilateral, etc. A severity score, if appropriate, is also assigned as follows: MINIMAL: The amount of change present barely exceeds that which is considered to be within normal limits. MILD: In general, the lesion is easily identified but of limited severity. The lesion probably does not produce any functional impairment. MODERATE: The lesion is prominent but there is significant potential for increased severity. Limited tissue or organ dysfunction is possible. SEVERE: The degree of change is either as complete as considered possible . or great enough in intensity or extent to expect significant tissue or organ dysfunction. COMMENT: Grades minimal through severe represent progressive involvement/severity along a continuum with minimal lesions being the least severe and severe lesions being the most severe. While the grades refer to the morphological characteristics of lesions, they also indicate their relative biological significance. Gross observations listing multiple masses for a tissue are distinguished with letters (i.e., a, b, c, d, etc.). 1405 Company Sanitized. Does not contain TSC CBI ip H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644438 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1406 MmBM H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644439 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE |a s f a s i isp ea JOUsaoQ "I 1407 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644440 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Does not contain TSCA CBS 1408 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644441 DAYS ON TEST: 43 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1409  Mmi v_ W * H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL #: 644442 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI ( i ) i. k 1410 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644443 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT'PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ibii Q>Sj, UjB|aoa jou saOQ 'psziyues iUBdfflQQ 1411 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL # : 644444 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE W i 4 i&fiUQ)OU s a o g -p 0 ^ 1 || 1412 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644445 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE kJ' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644446 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Bros ml.esoteta TSCIC81 1414 H -24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - F 1 ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644447 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS - DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE i SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Bees notsrtfalRTSCCBI 1415 W H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644448 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SanBfzed. Does noteonSanTSCA CB! 1416 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644449 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE fflpany Sanitized. Does mi e a rth s ?gg|s| 1417 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644450 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSC CBI 1418 k? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644451 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING-TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CeswpMfSanitized. Does no!contain TSOACBS 1419 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL #: 644452 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ',aj-u^ um iou seofl -jiueg rnurn^ St 1420 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL #: 644453 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1421 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL #: 644454 GROSS OBSERVATIONS: KIDNEYS DAYS ON TEST: 43 MODE OF DEATH: SD - DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SanHfeed. Doeoof eontafnTSCACBi 1422 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 ANIMAL #: 644455 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1423 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644508 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 0BpfSanRbed. Does notcontain TSCAenl 1424 w- H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644509 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ,,Doesnot contain TSCACB 1425 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644510 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE osnpanfSanitized. Does notconafnTSCA 1426 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY ANIMAL # : 644511 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS - DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE siiEiaos gou ssoQ "paifgjwg SmfmmQ 1427 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY ANIMAL #: 644512 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644513 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CosM*>V f e e d Does not eontaln TSCA CBI 1429 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644514 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Cosnpanf Sanitized, Does not contain TSCACBS 1430 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644515 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CBlpany Does no?contain TSCACBS 1431 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644516 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE smpany SanHIzed. Does not eonfafn TSCACBS 1432 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644517 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1433 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY ANIMAL #: 644518 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SanFifzee?. Does not contain TSC& n 73 1434 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644519 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized, Does not contain TSCACBI 1435 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644520 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644521 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE not contain TSCA CBS 1437 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644522 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644523 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE C w p a n f Sanitized. Does not contain TSC CB1 1439 " H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS MALE RATS GROUP: III-l DOSE: 50 MG/KG/DAY ANIMAL #: 644524 DAYS ON TEST: 43 MODE OF DEATH: SD '_ DuPont-4739 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. 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H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644577 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS MICROSCOPIC CORRELATE (selected lesions): - DILATATION, MILD, RIGHT, PELVIS > MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. 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ADULTS MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644581 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE i0O WOB1 Ei|8|uoa )ou m@g *pezj||UB$ 1446 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Ft ADULTS MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY M HP DuPont-4739 ANIMAL #: 644582 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS - DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE iBowpanf Sanitized, Does not contain TSCCP: 1447 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644583 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE pu a@a ] 1t*yWysa 1448 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644584 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Ccwpainy SanKIzed. 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Dobs not contain rse.4 CSI 1452 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: V-l DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644588 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Qompanf Sanitized. Does not contain TSCA CBI 1453 H-24616: Subcbromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644625 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS - DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY ANIMAL #: 644626 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 3 $i& 1 1455 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644627 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE O 83 O 1456 tp' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644628 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS - DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Carapwsf SanHfeed. Does not eonfain TSCACS 1457 m H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY m DuPont-4739 ANIMAL #: 644629 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE fflpanf' Sanitized. Does not contain T8CA CBI 1458 I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644630 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Cot"ParVSanm*Hf, Does no!confer 1459 > j H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644631 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1460 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644632 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE P H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644633 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE i.Dees no conta** `rSCA CB! 1462 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644634 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE orapwf Sanftfeed. D@snot contain TSCACBI 1463 W H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY m DuPont-4739 ANIMAL #: 644635 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Does net contain TSCA CBf 1464 e H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644636 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ' SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE p a y Sanitized. Does not contain TSCACBi 1465 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644637 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sempanf Sanitised. Does not contain TSCACBI 1466 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644638 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS : THYROID GLAND ALTERATION, COLLOID, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE wnpanf Sanitized. Bees nef eonfafn TSCAB! 1467 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644639 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE rapf Sanitized. Does not contain TSCACB 1468 I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644640 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE wmP' Sanitized. Doesno!contain TSCACf 1469 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644641 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 6 n p j Sanitized. Does not contain TSCCBI 1470 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY Wr DuPont-4739 ANIMAL #: 644642 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE W8pwjpianifeed Does netcontain TSCACBS 1471 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - F ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644698 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE I.Oms no?confafn TSCACB 1472 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644699 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ^ U^ UO01eoa 1473 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fa ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644700 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does not contain TSC CB 1474 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL #: 644701 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE OBparsf SanfitzedL Doss not contain TSCACBI 1475 8^ lip1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL # : 644702 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: .a H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644703 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Co*npany Sanftbed. Does not contain TSC C8I 1477 *%_ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL #: 644704 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE S&mpmtgSaniteed. Dees not containTSCAC8t 1478 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644705 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE "Does nocontain TSC CB 1479 I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644706 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized, Does not contain TSCA CB! 1480 if H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644707 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CtMqpaiqrSanitized. Does not contain ?SCA CSI 1481 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644708 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE MICROSCOPIC CORRELATE (selected lesions): > THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE MSpatSfSanRized. Does no! contain TSCA CSl 1482 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj, ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY IP DuPont-4739 ANIMAL #: 644709 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE -S * > J 1483 WC, H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644710 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS - DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized Sees notcontain TSCAcni 1484 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644711 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1485  H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644712 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does not contain TSCACBI 1486 9m_w H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644713 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ompanjfSanitized. Does not contain TSCACBP 1487 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644714 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does notcontain TSCAcgi 1488 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DuPont-4739 ANIMAL #: 644715 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE I 1489 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644770 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Cosnpanf Sanitized. Does net contain TSCACBI 1490 w H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644771 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions) MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE m N SB O USB> 5 a <o O 1491 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644772 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: LIVER - MASS, DARK, FIRM, RIGHT MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does oof contain TSCACBS 1492 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY ANIMAL #: 644773 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE * M 3 3a0sO* m (/> O > 1493 CoO : H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations __________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY ANIMAL #: 644774 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Stmapwj Sanitized. Does not contain TSCA 8) 1494 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644775 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE p@sm i eonaio TSCAcel 1495 kj H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644776 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE .CompanySanitized. Does not contain TSC CBI 1496 1J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644777 DAYS ON TEST: 43 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does no! contain TSCA C9 1497 w? X H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________ ____________________ _____ ______________---- .. INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ..... 1 -- ANIMAL #: 644778 GROSS OBSERVATIONS: KIDNEYS DAYS ON TEST: 43 MODE OF DEATH: SD - DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AOTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE. ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CompanySanitized. Does not contain TSCA CSI 1498 07 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644779 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE wnpanj? Sanitized. Does not contain TSCA GB1 1499 n/ / , H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY _ DuPont-4739 ANIMAL #: 644780 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Co" * a'V Sanitized. Goes not coma* r 03 1500 e, W H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY ANIMAL #: 644781 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE % THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE JiPBBpafy Sanitized. Does not contain TSCA CBf 1501 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY WM mtmrm DuPont-4739 ANIMAL #: 644782 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE MICROSCOPIC CORRELATE (selected lesions): > THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CompaRf Sanitized. Does nof contain T'p . 1502 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - F* ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644783 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Cowpanf Sanitized. Does no? contain TigcA**sf 1503 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations * INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644784 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ftfflPanjf Sanitized. Does notcontain TSCACSI 1504 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644785 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS - DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Dros not eontafr?TSCA3S 1505 C . ^ 2? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644786 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanitized. Does no! contain tsca CSS 1506 H-24616: Subchxonic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: IV-1 DOSE: 50 MG/KG/DAY DuPont-4739 ANIMAL #: 644787 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE D@es noteortain TSCACSI 1507 _ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY ANIMAL #: 644842 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE iSpnapanf Sanitized, Does not contain TSCA cm 1508 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY ANIMAL #: 644843 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE u ib j u o o 10 s e o o 'P 2 ia S ifaiu 1509 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644844 DAYS ON TEST: 43 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Sanlfe&* Bess nsf contain TSCA CB 1510 tr H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644845 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does notcontain TSCACBt 1511 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY ANIMAL #: 644846 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS - DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE s muoo i&ufse&Q-paiipiBsMmdmoQ 1512 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644847 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does not contain TSCA CB1 1513 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS FEMALE RATS GROUP: V I -1 DOSE: 250 MG/KG/DAY 3 DuPont-4739 ANIMAL #: 644848 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: BRAIN SOFT, CEREBELLUM MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE wnpatqf Sanitized. Does not contain TSCA C3 1514 Cf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________________________________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY ANIMAL #: 644849 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE P^$mHbedl. Does not eonisfn t<b* 1515 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644850 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1516 o H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644851 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does not contain ****) 1517 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644852 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS - DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Doesnotcontain TSCArs| 1518 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: VI-1 DOSE: 250 MG/KG/DAY DuPont-4739 ANIMAL #: 644853 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Doss no?eortaln *'**} 1519 u H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644889 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644890 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does not contain TSCA CBt 1521 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644891 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE TSCACB 1522 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644892 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ujb{uo9 |OU SSQ iuw 1523 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644893 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1524 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644894 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE f SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Dees notcontainTSCAC8i 1525 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644895 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does no!contain TSCACt 1526 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644896 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1527 If H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644897 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS : NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE I I 1528 TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644898 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE jjWwMi Does not con*a!n TSCA O 1529 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644899 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Bees not entela TSCA CBi 1530 v_ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fi ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644900 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: KIDNEYS DILATATION, RIGHT, PELVIS MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Bees sietcontain TSCA 1531 IOM H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644901 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1532 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644902 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Dees notcontain f 6if 1533 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY > DuPont-4739 ANIMAL #: 644903 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does notcontain TSCACS'l 1534  H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - F1 ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644904 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does notcontain TSCC$1 1535 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL #: 644905 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does not eortafn TSC CBl 1536 if H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DuPont-4739 ANIMAL # : 644906 DAYS ON TEST: 43 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: THYROID GLAND THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE \ THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 4 Does noi contain T8CA S il 1537