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C orporate O ccupational M edicine 3M Center, Building 220-3W-05 St. Paul, MN 55144-1000 651 737 4230 Telephone 651 733 9066 Fax 3. Mortality Study at the 3M Chemolite Plant This is the first update of the retrospective cohort mortality study by University of Minnesota epidemiologists.. The original study was completed in 1980 (see study # 2). The study population was defined as all hourly employees who were employed at least six months in the Chemolite (Cottage Grove) plant and, in particular, the Chemical Division. The roster of employees from the initial Chemolite study was updated to include new employees hired since the first study was completed. The study updated the vital status of employees through 1983. There were no statistically significant findings. There were three prostate cancer deaths observed versus one expected among Chemical Division employees. A nested case-control study was conducted of the prostate cancer deaths at the Chemolite site. For each case, four matched controls were selected. Individual job histories were reviewed to determine if any job titles or department codes occurred more frequently among cases than controls. There were no significant differences in department codes or job titles between cases and controls. The authors concluded that the greater number of observed prostate cancer deaths may be due to the higher prevalence of prostate cancer in Minnesota than the U.S. and/or a chance finding due to the large number of comparisons that were conducted. C-03142 Mortality Study at the 3M Chemolite Plant Jack S. Mandel, Ph.D , M.P.H. Leonard M. Schutnan, M 0., M.S. January, 1989 003143 Mortality StuOy at the 3M Chemolite Plant Introduction A retrospective cohort mortality study of the 3M Chemolite Plant in Cottage Grove, Minnesota was completed in 1980. The purpose of the study was to determine if the mortality experience of employees at this plant was sig nificantly different from that expected in a comparable population. The results from that study, surnnarized in a report issued in February of 1980, found no cause of death among employees which was significiantly greater than expected. On February 16, 1984, a contract was instituted to update the.initial study by evaluating the mortality experience through 1983. Specifically, it was agreed that the vital status of all former employees would be ascertained and a statistical analysis conducted to determine if there was any signifi cantly different cause of death among Chemolite Plant employees when com pared to the general population. Tnis paper presents the methods and results of the followup study. Methods The methods employed were essentially the same as those utilized in the initial study. The goal of the study was to determine the vital status of all inactive employees, obtain a copy of the death certificate for those who are deceased, and analyze the mortality data to determine whether there were any signfiicant excesses or deficiencies among Chemolite Plant employees compared to the general population. -1 - The study population was defined as all Hourly employees who were employed at least six months at the Chemolite plant. The roster of employees from the initial study (n3,688) was updated to include: 1. new employees hired since the first study was conducted; terminated (deceased, retired, 1aid-off, disabled, on leave, transferred) employees since 1978, the closing date of the initial study. Vital status was determined for all Inactive employees through Social Security Administration (SSA), the National Death Index (NDI) and tracing of individuals whose status could not be resolved by SSA or NDI. On August 15, 1984, a request was sent to SSA requesting a formal agreement for the ascertainment of vital status. Approval was received on October 15, 1984, and a computer tape containing 2,666 recoros was shipped to SSA on November 1, 1964. The results were returned on March 19, 1985. In August of 1984, a request for similar services was sent to NDI. Approval was received on October 16, 1984 and a computer tape was shipped October 29, 1984. The results were received November 20, 1984. Following receipt of the results of the SSA and NDI searches, death certif icates were requested from state health departments for all former employ ees known or presumed to be dead. Death certificates were coded by a professional nosologist according to the Eighth Revision of the International Classification of Diseases. -2 C03145 Employees for whom no vital status information was available were individu ally traced using a number of resources such as telephone information, reverse street directories to identify former neighbors, motor vehicle registration, former employers, church affiliations and unions. All data were coded and keyed for computer-assisted analysis. The method of analysis was based on a comparison of the observed to expected numoer of deaths by cause, adjusted for age, time, sex and race (Monson, 1974). Expected deaths were obtained from U.S. death rates. Nested Case-Control Study For any significantly elevated standardized mortality ratio, a nested casecontrol study was conducted. Cases were all deaths from the cause which was elevated and controls were four employees individually matched to the case on sex, race, birthyear (+^ 3 years), year first employed at 3M ( ^ 2 years) and vital status (alive at least until year of death of the case). The work histories of the cases and controls were examined to determine if there were any job titles or department codes associated with the oisease. Results A total of 4,085 employees (3,204 male and 881 female) were eligible for the study. These employees represented 67,684 person-years at risk (68,833 males and 18,851 for females). Vital status was determined for 100 percent of the cohort. Two hundred and eighty (71) were deceased and death certif icates were obtained for 278. Two died overseas; one in Korea and one in South America. Information on cause of death for those two deaths was obtained from the military for the Korean death and a family member for the death which occurred in South America. -3- 003146 It took from 20 to 341 days to obtain the death certificates from the state health departments. Si* states took over three months to respond. Table 1 presents the observed and expected number of male deaths, the ratio of observed to expected (standardized mortality ratios), the lower and upper 951 confidence limits and the chi-square value by cause of death. The SMR for all causes of death was 0.61 (951 C.l. * 0.54, 0.70), indicat ing a significantly lower than expected death rate among the Chemolite employees. A major contributor to this favorable mortality experience was the low rate of cardiovascular disease mortality, most probably reflecting a healtny worker effect. The SMR for all cancers was 0.76 (951 C.L. * 0.58, 0.97), a ratio significantly less than 1.0. *lo cause of death has an SMR significantly greater than 1.0. Table 2 presents the results for all male (100) deaths among employees in the Cnemical Division. The SMR's were 0.64 (951 C.L. * 0.52, 0.78) for deaths from all causes, 0.54, (951 C.L. * 0.37, 0.76) for deaths due to diseases of the circulatory system and 0.73 (951 C.L. 0.46, 1.10) for cancer deaths. The only statistically significantly elevated SMR was for prostatic cancer deaths where the observed number of deaths (4) was four times greater than expected ( S W 3.94, 951 C.L. 1.06, 10.08). Tables 3 and 4 present the results for all females and females in the Chemical Division, respectively. Based on a total of 35 deaths there were no statistically significant increased standardized mortality ratios. A nested case-control study was conducted for what were initially five prostatic cancer deaths in the entire study population. For each death 4. 002147 four matched controls were selected. Individual job histories were reviewed to determine if any job titles or department codes occurred more frequently among cases than controls. On reviewing the entire job history, it was apparent that one prostatic cancer death was duplicated. This occurred because the employee had been assigned two different identifica tion numbers and the records contained different dates of entry into the workforce. Thus, the case-control comparison was limited to four cases and 16 controls. The cases were employed in 16 different departments and had 11 different jobs, controls were in 25 different departments and had 27 different jobs. There were no significant differences in department codes or job titles between cases and controls. Discussion Employees at the Cneraolite Plant were found to have an overall lower than expected death rate than the general population. This occurred for both males and females and for both the whole Plant population and those employed in the Cnemical Division. The only exception was for deaths from pros" tic cancer among males employed in the Chemical Division where four deaths were observed and 1.02 were expected. Despite efforts to identify duplicate records, one pair was not discovered until job histories were reviewed in the nested case-control study. Removing the duplicate death reduced the SMR from 3.94 to 2.94. Even though this was no longer a sta tistically significant SMR, the case-control study was still conducted. No specific job title or department code was found to occur more often among cases than controls. Two possible explanations for the larger than expected number of prostatic cancer deaths are: (1) prostatic cancer is 5* G03148 more prevalent in Minnesota than the l l a n d thus a higher rate would he expected and (2) a chance finding due to the large number of comparisons that were conducted. The conclusion based on this study is that no statistically significant excess mortality was evident among employees at Chemolite. BEST COPY AVAUABLE 6- 003149 lAUtt I. OHjl.lt VI'I) AHO F.XtTr.tr.lt III AIMS IIY f.Air.E , S IArillrtnt! ZED fORTAlHY HAT to SI1R ), 95 I'EHCENT COlimiLHf.r LIMITS AND fill-SIJHAHE VALUE, MALES, CIIEMULITE TLAHT. 1 unsi avi* t o r n i l o 009/100 m ( iu m i or h u h 1*9 100.41 Iti .-- i l l iiiu u ta iii in o n a s i 11 i . t i -01? i h i iiirtcfivi H r ia ttin e oisiasi 1 s.u O .lf * m luotacuiosis i m t n i i i or oucmi v i l i m o rmoviM 14* M IRI* o r OICISIIVI 0MMS *1 rtOlM RIOt M U *- arroiMIIMIt 1 it* curio or iM M itw n * - arraoxiiM it i i *i cmrco or oidiikn i d trim or i*o*i iiitisin ic m u *- arrow iiM tti li* c u r ii or o iciu i M in - arrooKiiiait i it* h i c u c ii or i m o u t - orrooNHMiti i t m - rom aor o h n i curio o r m ir h ii i m i *- arrooK iiutt 1 i.st 1 1>** II IO.IO 1 I. * I.lt 1 a .ir 1 I.U 1 1.49 4 4.11 *.*l .so 1.04 I.SS l.t* l.o t .SI 0.*f .t* - n o m ir i* or M iruiiooT m i m u m . arrooxitiai 1 1 IO . 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I 0.10 .SO o.t* , t.s t 1.1* 4.1* 1.10 11.91 0 .* l O .tf *.l 0.1 0.01 1.1* 0.14 kf.r* t. r 1.91 0.00 II.fi .* l . f l 0.0* 4 .or 0.00 BEST COPY AVAUABLE r> 0 Includes duplicale 0o1 BEST COPY AVA ABLE 003151 '* uor.tttl IN) Alludili 10 MICIA or OliliII IVirilATIC 1ISSUE 11*50-1*4 UO.YI -- -IO* All ItllrllOfOIlllC CAIKti ite (linai iconisra M HUAC1C,Boem i,MIm o lle ,luiItUIOIIU 0ISIASI9 IIIH-HII UHV I no ni n n i muinis --- u i Ali o i u a s i s or uno aia looo-romiun ohqaih i im -. in a- Ar mo xm li* ikiimi,rivenutiunoue.ua r i n s a i u m eisoootni 1 1 *50-1*4* nvi ito m i oliia m i or inou 0*91(11 a semi oooMa -- M A All I I H I U I or CIOCUIATOOV (VSKII m cimane omuufic mnr oimottius- Ammarati <=%!*-AntiMoocitnotic iat o im a si. iiciuoiia tuo n * . rrnoxiiwii 1 io Ali VAocuiAo u s i a a or eia io a u Msriiuiooy ontAsti l i n i - , m ia - A m m arato 4*0 a h rm u m iu m - . i m - A m m arato 4*i iiniYiinA 11 n o - .m i Ammarato 4*1 Alili u n i - . 1 *10- AmoKIIMKI 10 Ali oi9(a h i or oiminvt svstih 111 a h Msinc a oudoihh c u ori ciMiiooio or i m o M O All OIOIA9I9 or CtllllO-UAIIUAY OYOttM 101 m a n e umilio ?0* All 019149(9 or TIM OfttN Aia CCllUMO tlOOUt ri* All ofsiAoto or via orna* u a oneun or inwoiir r** sYtmiaa.9tmiitv,Aia 1 1 1 otri c a a m a a 0(0 All (XIIWUl CAUS(9 or MAtH 0*1 All ACCIMIII! ot* raion VIHICU accibiiiio tl* (UIC101 101*1 MSItUH 1.15 J t.ia , *.! a 1.14 4 4.40 1 5.14 1 *.*! 1 i.4r 1 4.ir lo* 14*.Il 1 1.41 4 It*.40 r 14.91 r 1Y.1* 1 4.1* 1 1.14 1 0.5* it it.r* t I.YS 9 14.14 * 4.*I 0 1.41 * 0.14 1 o.r* 1 5.10 44 ri.ri 14 40.41 ir 14.ir * 14.1* t -1*4.14 0.00 0.00 1.14 0.15 0.44 0.11 *.** 0.00 0.40 0.14 0.(4 0.11 1.14 o.ot O.tt *.** *.00 0.14 .0.41 0.51 0.09 .ir Oil* *,4r 0.94 o.ir O.ll 0.19 0 .4* 0.1* *.tr 0.00 1.40 o.ot M* 1.41 o.tr 0.11 0.11 0.04 0.00 0.00 0.00 *.00 0.00 0.00 1.11 o.ot 0 .1* *. 0,41 0.44 10.10. 0.4* 1.01 0.40 0.94 0.14 -*.*l 1.IO 1.4* 1.1* t.l 1.51 1.44 4.41 1.40 1.00 o.r* 1 .4* *.*4 *.*r *./* 1 .1 * 1.4* .ir *.*t i.r* 0.41 O.tl i.r 14.or r.it 1.09 0 .*l *.** 1.5* 1.04 1.41 0.01 0.00 0.44 o.n 0.44 0.15 l.lt .ir (4.14 0.00 io.r4 4.14 r.n 1.19 1.14 o.ot 4.44 0.1* o.ot 1.1* *.40 O.ll *.** t.rt 10.04 4.11 0.00 t.n TABU 2. o b s er v ed and e x p e c t e d d e a iiis by c a u s e , sia m u a r d iz eo m o r t a lit y r a t io I s h r ) , 95 PERCENT CDliriDCMCE LIMITS AMI) CHI-SljUAHt VALUE, MALES, CHEMICAL DIVISION. iMir^tvivff tm c t t o iws/isr 1 U CUBIS or MIN ino ISi.lt #.* >1 il tiaucttaiir inoriism fi li.u O.M i m tmtctiv M m riattine oisiast * u hrhrcuiosm I) CUCIR Of RUCC*l Vili IO ttUatlM 1* c u c i r or R i m i r a orqmis u m riaitnaut n m - t r m i m m JI c u c i r *r i s o r m o w lift- m t ro m i im i i i III c u c i r or stmicN III CUCIR Of lROl llltlSIll i m . rrMMtlMItl Iti c u c i r or menai m i t - arrmeiiinici i a u calcia or i m a i m - arrmwitiaii i uro - m i w n w i y t.ti 0.00 n O.fO 0.00 o.to 0.00 r.ir 0.01 1 o.u 1.41 I.U 0.00 9 MI l.to * o.ro 0.00 o.ai 0.00 H r c u c i r or rucaai u t , arramiiiaii t t I.M 1.10 n o c u c i r nr ncsriaaionr m i n i u m - rratnuiiait II. 0.** h i c u c i r or i evict lit-, tit- arracciiiMiti \pi ail caie or ua n - rainaar u u sunualiv um -. it in - u-rtm:<iit*iti caie! or ooic u m - . i t i o - . i m - arrmmiiiaiii t MI * 10.0* 9 0.10 t.ll r.ir 0.00 Vlft c u c i r or sain }}< c d i a ' ' r i n M H m l - arronattMuT \ O.tl 44 t.ot 1.00 1.1* c u c i r or liona lotma ctimai maun i v t a - t t n u -wimiii 1 0.*l t.*t laa c u c i r or eiaoota u t . arraoKiiuiti o.u 0,00 gat c u c i r or m o m r u t , rraiwitiaici 9 0.0* 0.00 ivo cucia or ite utso-mt unti fl 0.01 o.no iti c u c i r or Rain ano outra t i m a n icamrs sismi u m - mnnuiian i 1 l.*l o.ro ! cucia or tntaoio utso-mt avi .ni 0.00 vie ivuriKHiacma ano Rimuiosaacnw u v i o - m t navi O.u 0.00 h i imonr.itrt Ristasi iim-.itss- arraoaimiti II a .15 0.00 II o.st O.M 0.00 0.00 o.oo 0.10 0.01 0.00 o.t* 0.00 0.00 0. 0 .1* 0.01 0.10 0.00 0.01 t.Oi o.ot 0.00 0.00 0.00 o.ei 0.00 0.00 o.nn ut cinsi o.ro It.t I.IO i.tr t.*0 0.10 I.T* i.rr r.os i.ir o.u 0.01 0.11 o.to o.o* o.ir I.SI a.ti .at 0.00 0.04 0.00 *.it o.no l.ot l.OS li. o.t* IO. a.t* lo.oo 11.4* 0.01 a.ir 0.01 i.n 0 .0* o.to t.oo 0.01 0.01 0 .1 I40.lt t.ll 1.01 o.oa Si.ir l.tl t.oo .or a.in O.tl! Includes duplicate BEST COPY AVAll ABLE ZSTVOO i (V M IX tlIlA AMO AUUMtlIA 10 CANCtR or OltltR tVIITIIATIC IISSUC ll* S 4 - IM * R.Y I . *0 n t ttirito ro u tic c u c t i t i * (16*1 I R m i S S . * AIIIRCIClOnOCRIIR>IKTAR0.1C taita ITtonal OlSfAStS III5 0 - IM * OMIV I M t RIAMTtS M U II tUS ( a u i m a m s or siooo t w looB-roM iun onoAiis u t i t - . m t - ppadkim mv n m u . n K m ( u m t i t i M M o sa u im isomus i i m - i n t an u K a u m u or irrvous sv su h m m k i r i t w w - IM A U OIMAStS or CIRCUIA IM t ststttt m i em an e H tu u iic m a m it t a s t im s - arrm wim t c i 410 ARItRIOSCltROIIC MAS? M U ASt ,llC lU D ItB CM0 IM S- AIYItOXItUfC I ASO A U VASCUIAR USIOMS OP CHS I I A U M t r ilA I M t OIMAStS IS IS -, 1114- AMHMMIMAfC I 40 A U rtKUW IIA t l l l S - . i m - ATPROMIHAIII u iirHYsittA t m a - . m s A m n K im tn 4*1 AStWIA m s - . i m - APrSOMIlUYtl S I* AU OIStAMS or O IM StlVt StSIltt t i l AU. OASIOIC AMO OUOMMAl UlCtR s n ciRAttnis or u n so A U m a s e s o r m m u o -uunart svstcn s a i cttRoiiie i n M i f i s ) | | A U RISC ASIS or IMt SKIM Al CCUUIAR TISSUi M* a u o is c a m s o r t i * o o k s ano oroaio or novuRitr r* s i B ,s u in n r.A m o t r i l ca aitio N s A U (RttRMAi CAUSIS OT MAM 01 A U ACCIDtNIS 1 ItOIOR V ttlIC lt ACCIOtlItS *S* SU1CIM 10IAL MSIOUAi 003153  i. 1 0 . 1 '*.7 0 o.so t t.s 1 t.os 0 0.11 1.47 i i.e i i i 1.17 t 1.1 ta 41.7 t MI a l.ll i t.14 1.17 l O.tt o .u t 0.71 t s.t a 1.01 a 0.07 0 0.10 0 0.10 1 t.17 tt 10.17 10 t i . IS 11 I t . 11 r 7.1 0 -10.OI 0.00 t.ia a.to 0.00 0.77 0.1 0.00 0.00 o. os 0*1 0.74 O .i 0.14 0.00 0.00 o.oo 4.47 1.00 t.O I O .If 0.00 0.00 0.00 0.00 0.4 0.77 0.70 1.00 0.10 0.00 0.00 t.70 0.01 0.00 t.ll 1.47 0.00 7.1* 0.0 t.7 f o.oi t.n 0.00 0.00 0.01 !. t.SO 1.00 0.17 o.ot 0.41 0.04 0.1 0.7 4. It O .lt l.M 1.40 0.10 1.0 0.00 t.oo 0 .0 t i . 00 0.4 O .lt 0.04 0.00 0.00 ` 0.00 1.11 10.1 I.IO t .40 .47 1.* 0.00 i t . 11 0.01 t.O 0.01 l.lt 0.4 1.71 O.SI 1.71 0.10 I.1S 0.54 0.1 1.10 0.00 0.00 0.10 0.00 0.04 0.00 it .s t o.ot O .lt 1.10 0.8 0.01 0.47 0.14 o .o t 0.00 1.7 0 . * o.ot !. t 0.11 O .ti l. 0 0.11 0.01 0.00 BES! COM AVMiMft- BIST COPY AVAIIABLE 003154 1*<m h risiuual TABLE 3 OBSERVED ANO EXPECTED DEATHS BY CAUSE, STANDARDIZED MORTALITY " j^ 10 (SHR), 95 PERCENT CONFIDENCE LIM ITS AND CHI-SQUARE VALUE, FEMALES, CIIEHOllTE PLANT. S S3 *11 causi* or KUR t *11 IMllCtlMIf iKorustts * u iw tctivt mio rm is i tic i i u k i DOSI* 1 I SU UMIKttMII iso c m ki* or oucct c*vm m m m m iih 14* e n e i* or m iriv i o*m m m n m i u i **- *rpmmiu*ti i 1*0 tM KII or ISOMAOUS (lftS- PPHOKIIMIt I ISI CMKI* or SIMtACN i n cm ki* or im m inii*iim u n * - m m im tii 1*4 cm ki* or nciut it m - rrnmimiti im * u cm ki or u h i l i * . ApruoMimui i m i - m iu n m i tir cmki* or pmkrim it m - rmoNimin i n cmki* or *tsriR*to*r m in i iim < rrnoxiiiMt i i*t cm ki* or imtim lift* - , in * - *rr*o*tmiii t u il cm k i or uno - r*ttu*r m m Mena*** iit t * - ,i* ic - pmuikhmici ir* c m k i* or ot* itm -,i*)*-,i*4 *- promiuAiti ir t c m k i* or Min 114 CMKI* or M IM I i*o c m k i* or clivi uttoi uno-m * m * i tot c m ki* or corno* v iir i utso-iu* im t u cm ki* or u uttous u *i*-m * novi it i cm ki* or ori* cinti ai ooca i t m - t m ri 1*4 CMKI* or ti WIIIm OOOMS im c*iKt* or 01*0*1* i m i - irrimdiMitt IO* CMKI* or R1MRV Ititi- rrMNItlll m cm k i* or t r i u tio -m * nnvt IKPICIIO ws/txr 14.41 0.44 t.li 0.14 o.tr o.tr . 0.14 0.41 1.** O.U t.S *.44 4.40 4.14 4.44 4.44 4.41 .il 4.00 0.11 0.04 4.40 t.4 O.M *.r* o.or 0.14 4.*r .** 4.4* 4.4* 4.Il 4.44 t.M 4.44 4.44 O.SI 4.04 I.U 4.04 I.BI 4.4* 1.04 4.11 *.ll 4.44 o.tr 4.44 4.41 4.00 ti 4.41 4.14 4.41 4.44 4.4* 4.44 4.0* 4.44 4.41 4.44 4.44 4.44 4.4* 4.4* 4.44 4.44 4.44 4.1* 4.4* 4.44 4.*4 4,4t 4.40 4.44 4.1* 0.44 Ut eluso 4.0* I.U l.4t 0.14 11.1 11.14 1.44 11.44 I.U 4.41 4.t *.t* l.tl 4.14 4.44 1.4* 4.41 4.41 II.41 4.44 11.44 4.14 *.41 4.4* t.4f 1.44 t.l* 44.4 ll.lt V.41 4.4* l.tt 4.41 1.41 4.4 4.44 .* 4.14 * r.t* 4.00 t.41 4.14 i.tr 4,44 t.M 4.T4 tr.il 1.0 ii.it 4.M tri.> w.i* 003155  u c<nn BEST COPY AVAI1ABLE iv i C M ctn of d r a iii urn o iiier c im ir a i nervous s t s ie ii n i t s - r r n u x iiu in * C M K tR o r THYROID I 1SS0 -1S4 OMIT 1 too IT ir ifO S R R C n U M ID RETICUU8 AACOMA 1 1 * 5 0 -11 4 O tHVI t o i MOOCK1N ** D ISE A S E 1 I H I -. 1H S - rrROXIIUM E 1 t 04 lEUREIIIA I A LE IK IH IA tOD CA IKER o r O IIIIR IV IP t U T IC TISSU E 1 1T5 0 - 1T4 * w a v i ISO A ll ETHPUO rolETIC CAWED n o ottit cm i c o n asms n o A l t t M I C i c m o c o i W M TAO O LICIAITA1T 10MAI OTSEASES I M 5 0 -M 4 T ONLY 1 ISO OIAOCTIS M EltlTU S to o A l l D IS E A S E S 00 OlOOO AI OIDOO-TOOHII 0 0 0 l i m - , M IO - A P rm m lll I I W H T A l,O S V C in U R O TIC ,H PERSONALITY DISORDERS I M I O - M M V I 110 A l l D ISE A S E S OT NERVOUS SVStEt M O S E IB E OMANS 1 A U D IS E A S E S OF CMCIN.AIORV SYSTEM IT S CHROIIIC R H E U IA IIC W ART D IS IA S E I U S - APP0 0 MIMA1E 1 A ID AflICRtO SCtCRO TtC HEART DISEASE lt C lU D I I CHS I l T t S - AFMtOMitUtt 1 A ID A U V A K U 1 AA IE S IO H S DT CMS A ID A U RESPIRATORY DISEASES I i m -,1 U 0 - ArPRO M IIU II 1 A ID A U PNEIAERHA I I V I S -.M IO - APPM M IIIAIC1 A ft EMPHYSEM U M - . I M S APPRQNIMTEI A T I AST U t s -.I 1 0 - A r r M M iiu t ii S ID A U D ISE A S E S DT D 10E ST IV E STSTCH s t l A U 0 ASTR1C N 0 DUODENAL UECER T I CIRRHOSIS OP IIV E R 100 A U D ISE A S E S OF C EIIITO -U R IIU R Y S V S IE H 10t CHROMIC IH P H A IT IS TO A U D IS E A S E S DT THE S E IN AMI CELLULAR ISSU E T I A U D IS E A S E S DT TIRE DOMES AI ORCAItS OP N D V E ItllF i t S Y N P ia is .s c H i i i r r . i u d e f i i k o c o n d it io n s 00 A U EXTERNAL CAUSES DP K A I N 1 U 1 0 0 o o 0 1 0 0 0 0 1 II 0 * I t 0 0 1 I 0 0 0 0 0 I A 0 .4 1 O.OS O .SI O .tl o .tl O.AA 1 .4 0 O .IS 1 .1 0 O .tl 0 .1 1 H .TA o .s I .1S 0 .0 0 .1 S .tA 0 .1 * !. t O.T* O .tt 0 .0 * 0 .1 1 O.TI A.tS 1 .4 0 0 .0 0 0 .0 0 0 .00 0 .0 0 0 .0 0 0 .0 0 1 .00 0 .0 0 0 .0 0 0 .0 0 0 .0 0 1 .1 1 0 .44 0 .0 0 0 .4 0 0 .1 0 0 .0 0 0 .0 0 0 .0 0 o .ts 0 .4 1 0 .0 0 o .o o 0 ,0 0 0 .0 0 0 .0 0 o .o o 1 .48 0 .4 4 0 .0 t 0 .0 0 0 .0 0 0 .0 0 0 .0 0 0 .0 0 0 .0 0 0 .04 0 .0 0 0 .0 0 0 .0 0 0 .0 0 0 .0 1 0 .1 1 0 .0 0 o .ts 0 .0 0 0 .0 0 .0 0 0 .0 0 O.OT o .o r 0 .0 0 0 .0 0 0 .0 0 0 .0 0 0 .0 0 0 .00 0 .0 t r . it 0 .0 0 T T .4 t 1 1 .1 0 1 4 .1 1 4 .0 4 0 .10 1 .1 0 1 4 .4 0 t .40 I.IO I T .l II.T O 4 . IT I .1T I.O S 1 .4 1 .4 4 t.fO 4 .1 0 1 1 .4 1 t* .tl l.f t 1.S I l. l 4 .4 t 1 4 .S 4 I T . 14 11. TI T .00 1 .4 4 0 .0 t 4 .1 4 0 .0 0 .1 1 0 .0 t 0 .0 1 0 .0 1 0 .0 0 0 .4 0 .1 0 .4 0 0 .1 1 0 .1 0 1 .4 S O .tt 0 .58 1 .0 1 0 .0 0 o .ir 0 .1 0 0 .1 0 0 .1 0 o .s i I.O S o .ll O .IS I.TO O.ll 0 .0 4 O.M O o M Vu*\ BEST COPY VA ABLE TABLE 4 . OBSERVED AMD __ _____ _ EXPECTED DEATHS iiuirr nv CAUSE, STABOARDIZED un m i .cnilA&F UAl Itr . mortalit FEMALES, y r a t t o (s h r ) CHEMICAL DIVISION. I onstAvto tx rt c t to OOS/IN l i CAUSI Or M A I* 1 04.41 0.44 i u iM uauur tK orusm I I 14.14 .or t u untem i m n iu m t iK it n * A ll 1W (K W N II m i c a ir i or m e d i c a v itr pimnyim U t c u c i or le it t iv t o n u ii aii r t R im a u t i m i i - rmoMiiuic i m c r u c i* or i n f i w u u m - m u m m ie i t u c r ir ih or o tn u c* t u CAIRI or l*00 IH ItS U ) l i t i o - PPMMIIUIt 1 0.44 o .ir o .tr 1 0.40 0.14 0 0.41 1 1.04 1.04 0.00 0.00 0.1 *. O.M 0.41 1U CAIRI or u h m u n i - p rM xim ttt 0 0.11 0.00 t u i l c u r i or u v t * i i n i ' ppo n in m ii m o t - m ih a r t n a v *? CAIRI or PMCRIAS u m - ArrMMIHMtt 0 0.11 0.0 0 0.40 0.00 HO C A IR I* or RtSPtNAIMV U IIIM l i t i - M TM XIIM It I l.o t 0.44 t u c a ir in r lARm t u m - , t u o - i r r m n w i d 0 0.04 . u t i l Ca ir i or iuho - rnwT Aia u co iw M r u m - , i n o - m u m m it i ( t.f* *.rt ir c a ir ia or o o ir n n i - , i m - , i t i - A rrnoKiiuii IT I CAIRI* or U H I IH CAIRI* or M IA ir o 0 .0 ? I 1 ,1 1 4 4.4? 0 .0 i.* 4 0 .0 t u Ca i r i * or c i* v ix 1**1 itn o -iM t o irti 0.4* * .* io i Ca i r i * or conni o u * i tm o -m navi 0 0 .0 1 I.H i t i Ca i r i * or A ll u n u m u ilo -m r a a n l.o t 0.00 u t c a ir * or otm * c u iiia i o r iio u m -m t navi 1 1.01 0.44 104 C A IR I* or A ll C tH IIA l 0A0MS 100 C A IR I* or 01A0H* l l f t f - m u m m ie | 1 1.04 0 0.11 0.11 0 .4 * I O C A IR I* or M M T u m - APPAOMIIHII t 0 o .tr . 140 C A IR I* or I I I im o -itti n avi 0 0.01 . Il 0.40 Ul 4.44 e lu sa 4.41 0.10 1.41 l.lt 4.4 . 0.00 * . . .4 O.OI 0.40 0.00 . A4 01.14 11.14 1.94 1, 4.4 0.44 11.41 11.44 4.01 4.41 4.1 I.H 4.94 4.41 4.41 0.4 0.00 0.41 0.00 1.4 0.44 0.0 0 .0 0 0 .0* .04 .Il . *.0 41.44 t.4 04.44 10.01 0.44 S.tt 7.1# 4.41 1.41 4.44 4.14 4.44 O.M t.4 t 4.4 0 .0 1 l.* l 4,4 0.00 1.41 4.10 0 .0 0 t r .n 1.40 *. 11.01 4.14 0.4* 1M .M I I . SO BEST COPY AVAII ABLE 003158 IVI CIUCHI OF MAIM U U Otiti* CIM IM I HIRVCUS S t i l i l i IM IS - trPROKHMIIl i t s entice* or tn tm t* tm i- im an ti too iYiH03A*caA m Rtm uiosincaw i i f s o - i t t t a i m h i M ocxitrs m u s t i i t n - . i m - im o x n u it t 10 ItUMIItft 11 IlfU K IH tl MO C U CIR or OtNCR IVtUMATIC T1SSUI U f S O - I f lf ONLtl to* h i iw ra a ro itT ic cu e * no itm w in n i * m o *U (*o ic,ii*m :R ii >ic t i* o c ic .iu iR m a u i o i s i i s t s m s o - i f t * an eti too t i n n i i r a u t t u s too m i m u n i or oiaoo m m oiaoo-roomra ooeuis i i m - . t m - irrmnun it * n tm iitro ci o K JR am *w riRsatM itv oisorm rs i m i - m * aneti it * m i m is t s or MRvoui o tsittt u n tem o onoun n o m i m is t s or cio cu u io rt ststtn i t i cim auc in tu irn e n ti*r s m is t i i f is- irn ra x iiu iti 410 SRttRlOSCltROIlC K i l t m i s t .IIC IU O IIU CHS u n i ' UTROXIHItt t *1 M l v sscu iu t lis t e n s or cms *1 M l MSMNMORV m i s t s 1i m - . I f l * - IMRONIIMItl m o m i m u n i i * u n - .it i * - ipfro xiiu t i * * t tHRNYStttt Ilf t O - .lf S S IMROXIIttfl 1 i n isfw u u n i- .it i* - sm oKiiurti it * m i m is t s or sio tsriv t ststtn n i l l o iit R ic m m oudmnm u cci* m cirrhosis or u *m iso m i m i s t s or ctm to-uiiM iRT sts itH t i t CHROMIC HtWI*llS r*t m i o t s t is t s or tut s u i t itu c iu u u r tissu e n * M l o is t is t s or tne sa te s u n ooeun or tu v n ciir m sT tirto n s.sttiiim .u n i l l o trn cs c o w m a n wo m i tx ttu u i cu nts or n i i i * .t t 4.4 o.os 14.01 0.14 *.ot 0.00 0.00 M I. 14 11.04 f .It .OF 0.00 0.00 0.00 O.M S0.S4 4 * .St l.to t.4S 0 O.CI 0.00 0.00 I F . 14 0.1* 0 .It 0.00 0.00 11.4 .It 0 0.41 0.00 0.00 4 .Of o .o t O .lt o.sr 0.00 0.00 0.00 O.M 1 0 .*F 4.41 l.t l 0.01 0.44 0.00 0.00 O.M 0.01 0 0.00 0.00 0.00 4 .SS t.so 0.11 0.00 0.00 SI.4S t.lf .ft 0.00 0.00 11.4 0.1* s 4 .SO o .tr O.M l.F * O .lt 0 .IS . 0.00 O.M 10.SI O.OF 1 1.40 0.04 .I t t . s t 0.00 1 I.IF O.M 0.01 4 .IF 0.04 0 O .fl 0.00 0.00 i.n O.M 0 *.ss 0.11 0.00 0.00 0.00 0.00 11.14 tf.lt .O f l.lt *.r O.M 0.00 M .tF t.FF 1.1* 0.00 O.M 1.1* O .tf 0 s.o r 0.00 0.00 S I . 04 t.SS 0.4* O.M 0.00 S.M 0.01 0 *.t* O.M 0.00 lt.t* 0.14 0 0.0* *.* 0.00 4 8 .OF t .ll 0.01 0.00 0.00 I I I . I f .11 0 Ml 0.00 0.00 I t . 14 l.lt 0 o.ts 0.00 0.00 14.i f O.M 1 t.01 0.4* o.ot t.F4 0.14 UNIVERSITY OF MINNESOTA TWIN CITIES Division ol Environmental and Occupational Health School of Public Health Box 197 Mayo 420 Delaware Street S.E. Minneapolis, Minnesota 55455 April 6, 1989 Larry R. Zobel, M.D. Staff Physician 3M Center Medical Department 220-2E-02 St. Paul, W 55144-1000 Dear Larry; Enclosed please find the tables containing the results of the comparison with the Minnesota population. As I mentioned on the telephone, these must be interpreted cautiously because of the uncertainty regarding the Minnesota rates prior to 1959. Deaths among the study cohort occurred in 41 states; therefore, the U.S. rates may be more appropriate. As you will see from the tables, the results are similar to those presented previously which used the U.S. rates. The only consistent finding between the two comparisons is for prostatic cancer which we addressed in our initial report. For cancer of the digestive organs and peritoneum there was a statistically significant excess (SMR=176, 95% C.L.=1.09, 2.69) for the entire cohort. However, this was not found among the Clinical Division employees. Furthermore, no single site within the gastrointestinal tract was elevated suggesting that this was probably due to chance. Also worth noting is the fact that these are not sites typically associated with chemical exposures. If you have any questions please feel free to call me at 626-4810. erely, px S. Mandel, Ph.D. soci ate Professor HEALTH SCIENCES 003159 IABLE 5. OBSERVED AND EXPECTED DEATHS BY CAUSE, STANDARDIZED MORTALITY RATIO (SMR), 95 PERCENT CONFIDENCE LIMITS AND CHI SQUARE VALUES, MALES, CHEMICAL DIVISION (COMPARED TO MINNESOTA DEATH RATES) , OALL CAUSES OF OEATII OBSERVED EXPECTED 100 09.79 OBS/EXP 1.11 m i MALIGNANT IIEOPLASHS 23 16.39 1.40 IAIL INFECTIVE AND PARASITIC OISEASE 0 0.60 0.00 9 A U TUBERCULOSIS 1ABCAIICEft OF BUCCAL CAVITY AND PHARYNX 149CAICER OF OIGESTIVE ORGANS AND PERITOIIEUI 11925-APPROXIMATE) ISOCANCER Of ESOPHAGUS (1925-APPROXIMATE) 151CAIICEA OF STOMACH 0 0.20 0.00 0 0.52 0.00 6 4.23 1.42 1 0.40 2.49 U 0.71 0.00 ISICAMCEft OF LARGE INTESTINE 11925-APPROXIMATE) 3 1.40 2.14 154CAMCER OF RECTIII (1925-APPROXIMATE I 0 0.45 0.00 1SSALL CANCER OF LIVER (1925-APPROXIMATE > 1970 PLUS-PRINARY ONLY 0 0.27 0.00 1S7CAICER OF PANCREAS (1925-APPROXIMATE1 2 o.aa 2.28 l&OCANCER OF RESPIRATORY SYSTEM (1925-APPROXIMATE) 5 4.66 1.07 141CAMCER OF LARYNX 11925-,1930- APPROXIMATE) 1 0.19 5.16 162ALL CANCER OF LUIG-PRIHARY AND SECONDARY (1925-,1930-APPROXINATE 1 6 4.41 0.91 170CAIICER OF BONE 11925-, 1930,1945-APPROXIHATE) 0 0.12 0.00 172CANCER OF SKIN 1 0.40 2.49 ISSUANCES OF PROSTATE (1925-APPROXIMATE) 4.. P.51 .7#0 1B4CAMCER OF TESTIS 1OTHER GENITAL ORGAMS-1925-49) (1925-,1930-APPKOXUIA 1 0.3a 2.61 1BBCAICER OF BLADDER (1925-APPROXIMATE) 0 0.26 0.00 1B9CAICER OF KIDNEY (1925-APPROXIMATE ) 0 0.53 0.00 190CAMCER OF EYE (1950-1969 ONLY) 0 0.02 0.00 191AICER OF BRAIN AID OTHER CENTRAL NERVOUS SYSTEM 11925-APPROXIMATE) 1 0.S7 1.15 193CANCER OF THYROID (1950-1969 ONLY) 0 0.04 0.00 *tOOLYtVHOSARCOHA AND RETICULOSARCOMA (1950-1969 ONLY) lOlHOOGKIN'S DISEASE (I960-,1965-APPROXIMATE) 0 0.52 0.00 0 0.55 0.00 IL 0.91 0.09 0.00 0.00 0.00 0.52 0.03 0.00 0.43 0.00 0.00 0.26 0.35 0.07 0.24 0.00 0.03 2.10 0.03 0.00 0.00 0.00 0.02 0.00 0.00 0.00 UL 1.35 2.11 5.41 18.48 7.05 3.09 13.83 5.16 6.25 0.23 13.60 0.23 2.50 28.73 2.32 29.60 13.85 19.96 14.55 14.08 6.91 181.46 6.42 93.44 7.04 6.62 emsq 1.05 2.27 0.05 0.46 0.00 0.38 0.02 0.06 o.a6 0.01 0.20 0.44 0.01 0.48 0.00 1.14 0.02 17,39 0.04 0.22 0.00 11.39 0.15 5.41 0.00 0.01 BEST COPY AVAII ABLE O CO eg Oo Z04LEUKEMIA AI ALEUKEMIA ZOSCANCER OF OTHER LYMPHATIC TISSUE (1950-1969 ONLY) Z09ALL LYMPHOPOIETIC CAMCER ZIMEIIIGII NEOPLASMS (PLUS UNSPECIFIED) Z40ALLERGIC.ENDOCRINE.METABOLIC.NUTRITIONAL DISEASES 11950-1969 OMLY) Z500IABETES MELLITUS Z80ALL DISEASES OF DLOOO AMO BLOOD-FORMING ORGANS (1925-.19S0-APPR0XIMAT 319tEMTAL,PSYCHOMEUROTIC, AMD PERSONALITY OISOROERS 11950-1969 ONLY I 320ALL DISEASES OF NERVOUS SYSTEM AII0 SENSE ORGANS 390ALL DISEASES OF CIRCULATORY SYSTEM 393CHROIIIC RHEUMATIC HEART DISEASE 11925-APPROXIMATE I 410ARTERIOSCLEROTIC HEART DISEASE. 1MCLU0IMG CIID (1925-APPROXIMATE ) 430ALL VASCULAR LESIONS OF CMS 460ALL RESPIRATORY OISEASES (1925-.1930-APPR0XIMATE I 480ALL PNEUMONIA (1925-.1930-APPR0X1MATE I 492EIF1IYSEMA (1950-,1955 APPROXIMATE) 493ASTIRIA (1925-.1930-APPROXIMATE ) 5ZOALL OISEASES OF DIGESTIVE SYSTEM SS1ALL GASTRIC AID DUODENAL ULCER S7ICIRRN05IS OF LIVER SMALL DISEASES OF GEMITO-UR1NARY SYSTEM MZCHROMIC NEPHRITIS 7D9ALL DISEASES OF THE SKIN AIID CELLULAR TISSUE 739ALL DISEASES OF THE BONES AND ORGANS OFMOVEMENT -- 799SYIETONS,SENILITY,ANO ILL DEFINED CONDITIONS SMALL EXTERNAL CAUSES OF DEATH SOIALL ACCIDENTS SIOMOTOR VEHICLE ACCIDENTS -9S9SUICIDE TOTAL RESIDUAL 0 3 6 0 9 3 1 1 3 104 3 B4 7 7 3 1 1 12 2 3 0 0 0 1 1 46 34 27 9 1 2.63 1.42 6.69 0.49 4.74 3.71 0.44 1.06 3.21 96.73 2.09 72.08 10.50 0.68 3.09 1.95 0.43 11.45 1.12 6.08 2.16 0.91 0.14 0.52 1.66 52.17 38.27 21.42 10.86 -65.08 0.00 2.11 0.90 0.00 0.84 0.81 2.28 0.54 0.94 1.08 1.04 1.15 0.66 0.81 0.97 0.51 2.34 1.05 1.78 0.44 0.00 0.00 0.00 1.94 0.60 0.88 0.89 1.26 0.83 -0.02 0.00 0.42 0.33 0.00 0.23 0.16 0.03 0.01 0.19 0.88 0.21 0.92 0.26 0.32 0.20 0.01 0.03 0.54 0.20 0.09 0.00 0.00 0.00 0.03 0.01 0.65 0.62 0.83 0.38 1.40 6.15 1.95 7.50 2.16 2.36 12.68 3.00 2.73 1.30 3.03 1.43 1.36 1.66 2.84 2.86 13.02 1.83 6.44 1.27 1.70 4.04 26.14 10.78 3.36 1.18 1.24 1.83 1.57 1.72 0.81 0.01 0.00 0.01 0.01 0.01 0.07 0.03 0.47 0.05 1.55 0.90 0.16 0.05 0.10 0.01 0.00 0.13 1.66 1.27 0.18 0.92 0.00 0.01 0.62 0.37 1.20 0.17 U sss > au o U ! CO GUI tt ri H O O CANCER RESIDUAL 13 3.00 4 .3 3 C03162 TABLE 6. OBSERVED AND EXPECTED DEATHS BY CAUSE, STANDARDIZED MORTALITY RATIOS (SMR), 95 PERCENT CONFIDENCE LIMITS AND CHI SQUARE VALUES, MALES, CHEMOLITE PLANT (COMPARED TO MINNESOTA DEATH RATES) OBSERVED EXPECTED OAll CAUSES OF DEATH 295 231.99 M U . HnUGNAtir IIEOPLASItS m i INFECTIVE AND PARASITIC DISEASE 63 99.29 1 1.79 All TUBERCULOSIS 140CAHCER OF BUCCAL CAVITY AT PltARYIK 149CANCEK or UICEST1VE ORGANS AMD PERITOMEUU 11925-APPROXINAIE1 150CAIICER OF ESOPHAGUS 11925-APPROXIMATE) 1 0.56 1 1.92 21 11.93 3 1.19 151CANCER OF STOMACH 4 2.06 1SSCAMCER OF LARGE INTESTINE (1925-APPROXIMATE) 154CAHCER OF RECTUM 11925-APPROXINATE ) 7 3.69 1 1.27 IBSALL CANCER OF LIVER 11925-APPROXINATEI 1970 PLUS-PRIMARY ONLY 1 0.76 157CAIICCR OF PANCREAS 11925-APPROXINATE) 9 2.97 UOCAIICER OF RESPIRATORY SYSTEM 119Z5-APPROXIMATE 10 12.95 U1CAICER OF LARYNX 11925-,1910- APPROXIMATE! 162ALL CANCER OF LUNG-PRIMARY AHD SECONDARY (1925-,1930-APPROXIMATE) 1 0.59 9 12.27 UOCAIICER OF BONE 11925-,1930,1945-APPROXIMATE 1 0 0.2S 172CANCER OF SKIN 1 0.96 MSCAIKCR 0> PROSTATE (1925-APPROXINATE 1 "5 69 1MCAICER OF TESTIS IOTIIER GENITAL ORGAIIS-192S-491 11925-,1930-APPROXIMA 1 0.81 1B0CAICCR OF BLAOOER (1925-APPROXINATE ) 1 0.7 189CAMCER OF KIDNEY 11925-APPROXINATE 1 1 1.95 190CAICER OF EYE 11950-1969 ONLY 1 0 0.06 191ANCCR OF BRAIN AIIO OTHER CENTRAL NERVOUS SYSTEM (1925-APPROXINATE I 3 2.16 19SCAIICER OF THYROID 11950-1969 ONLY) 0 0.10 200LYMPIIOSARC0MA AMD RETlCULOSARCOttA (1950-1969 ONLY! 1 1.32 201H00GKIM'S DISEASE 11940-,1945-APrROXIMATE 1 2 1.25 OOS/EXP 1.06 1.92 0.57 1.7B 0.70 ' 1.76 2.63 1.99 1.00 0.78 1.32 1.62 0.77 1.89 0.73 0.00 1.05 7T9T 1.29 1.27 0.69 0.00 1.39 0.00 0.76 1.59 LL 0.93 1.09 0.01 0.02 0.01 i.o9 0.53 0.52 0.72 0.01 0.02 0.99 0.37 0.02 0.33 0.00 0.01 o:6 0.02 0.02 0.01 0.00 0.20 0.00 0.01 0.10 UL 1.20 1.82 3.19 9.8B 3.91 '2.69 7.69 9.97 3.70 9.37 7.32 9.15 1.92 10.22 1.39 12.97 5.62 6192 6.91 7.07 3.69 61.93 9.06 35.80 9.23 5.76 CIIISQ 0.79 7.99 0.03 0.01 0.00 6.16 1.62 1.00 1.79 0.04 0.09 0.43 0.47 0.00 0.62 0.17 0.22 4.70 0.12 0.10 0.00 3.25 0.05 1.54 0.03 0.05 BEST COPY AVAILABLE CO CoO 206LEMKEMIA AMO ALEUKEIIIA 200CAMCER OF OTHER LYHPMATIC TISSUE 11950-1969 OIILY I 209ALL LYMPHOPOIETIC CANCER 2106EMIGM NEOPLASMS (PLUS UISPECIFIEOI 2A0ALIERGIC,ENDOCRINE,METABOLIC.NUTRITIONAL DISEASES (1950-1969 ONLY) 2S00IABETES MELLITUS 260ALL DISEASES OF BLOOD AMO BLOOO-FORMIM6 ORGANS (1925-.19JO-APPROXIMAT J19MENTAL,PSYCHO!IEUROTIC, AMO PERSONALITY DISORDERS (1950-1969 ONLY) 320ALL DISEASES OF NERVOUS SYSTEM AMD SENSE ORGANS J90ALL DISEASES OF CIRCULATORY SYSTEM 393CIIR0NIC RHEUMATIC HEART DISEASE (1925-APPROXIMATE ) 610ARTERIOSCLEROTIC HEART DISEASE , INCLUDING CIID (1925-APPROXIMATE t 6SOALL VASCULAR LESIONS OF CNS 460ALL RESPIRATORY OISEASES (1925-,1930-APPROXIMATE ) A80ALL PNEUMONIA (1925-,1930-APPROXIMATE1 A92EMPHYSEMA (1950-,1955 APPROXIMATE) 493ASTIBIA (1925-,1930-APPROXIMATE ) 0 S20ALL OISEASES OF DIGESTIVE SYSTEM 531ALL GASTRIC At DUODENAL ULCER S71CIRRII0SIS OF LIVER S M A L L DISEASES OF GEMITO-URINARY SYSTEH S82CIW0IIIC NEPHRITIS 709ALL OISEASES OF THE SKIN At CELLULAR TISSUE 9 7S9ALL OISEASES OF THE BONES ANO ORGANS OF MOVEMENT ""799SYMPTOMS,SENILITY.AND ILL OEFIMED CONDITIONS 9 MO A L L EXTERNAL CAUSES OF DEATH M l ALL ACCIDENTS 9 OlOMOTOR VEHICLE ACCIDENTS --m9S9SUICIDE fl TOTAL RESIDUAL 0 1 1 0 Z 1 0 0 1 33 1 za Z 4 Z 0 1 9 Z Z 0 0 0 0 X n 16 13 7 0 1.06 0.53 Z.69 0.19 1.85 1.45 0.18 0.7Z 1.32 39.09 1.09 Z5.65 3.61 3.10 1.13 0.64 0.16 4.36 0.40 Z.63 0.84 0.36 0.05 O.ZQ 0.66 Z4.6Z 18.19 10.59 4.94 22.74 0.00 1.89 0.37 0.00 1.08 0.69 0.00 0.00 0.76 0.97 0.91 1.09 0.55 1.Z9 1.77 0.00 6.37 Z.07 4.96 0.76 0.00 0.00 0,00 0.00 1.51 1.10 0.99 1.23 1.42 0.00 0.00 O.OZ 0.00 0.00 0.12 0.01 0.00 0.00 0.01 0.67 0.01 0.73 0.06 0.35 0.20 0.00 0.08 0.94 0.56 0.09 0.00 0.00 0.00 0.00 O.OZ 0.72 0.59 0.65 0.57 3.47 10.54 Z.07 18.83 3.91 3.84 Z.78 5.06 4.ZI 1.36 5.09 1.58 Z.00 3.30 6.39 5.71 35.42 3.92 17.91 Z. 74 4.36 10.06 67.56 18.37 8.40 1.60 1.56 2.10 Z. 92 0.29 0.00 0.52 0.48 0.07 0.00 0.59 0.07 0.02 0.01 0.15 0.13 0.34 0.05 0,12 0.03 0.75 3.94 2.98 0.01 0.14 0.05 3.66 0.45 0.04 0.14 0.01 0.34 0.49 O H P3 O O kfcir mmt g SE 58* tesi. SI |w SS SB CUCBH r e s id u a l 4 1.16 3.46 002165