Document 0Lbranj38d1xQ602EO98deQmM

Message From: Sent: To: CC: Subject: Roy Bailey [rbailey@gdcillc.com] 7/28/2017 2:31:26 PM Beck, Nancy [/o=ExchangeLabs/ou=Exchange Administrative Group (FYDIBOHF23SPDLT)/cn=Recipients/cn=168ecb5184ac44de95a913297f353745-Beck, Nancy] Bennett, Tate [/o=ExchangeLabs/ou=Exchange Administrative Group (FYDIBOHF23SPDLT)/cn=Recipients/cn=lfa92542f7ca4d01973bl8b2fllb9141-Bennett, El]; Brown, Byron [/o=ExchangeLabs/ou=Exchange Administrative Group (FYDIBOHF23SPDLT)/cn=Recipients/cn=9242d85c7df343d287659f840d730e65-Brown, Byro]; Gay Ludwick [gay@gdcillc.com] Re: Wolbachia doc Nancy That certainly makes sense, thanks much. I will send you a thorough analysis in the next few days. All my best Roy W. Bailey CEO Giuliani Deason Capital Interests, LLC I Cell Ex!" 6 [ Officej___ x. 6___ j Rbailey@gdcillc.com Rbailey@baileystrategicadvisors.com On Jul 28, 2017, at 9:11 AM, Beck, Nancy <Beck.Nancy(Sepa.gov> wrote: Roy, Thanks for the heads up. It would probably make sense for the OPP experts to take a look at what will send and digest it a bit before we have a follow-up meeting. Next Tuesday/Wednesday may be a bit too soon, but we can make that call once we have more materials from you. Regards, Nancy Nancy B. Beck, Ph.D., DABT Deputy Assistant Administrator, OCSPP PM::2C02Z-5Z6l4iZ-1i2Z7Z3 Zj beck.nancy@epa.gov From: Roy Bailey [mailto:rbailev@gdcillc.com] Sent: Friday, July 28, 2017 9:02 AM To: Beck, Nancy <Beck.Nancy@epa.gov> Cc: Bennett, Tate <Bennett.Tate@epa.gov>; Brown, Byron <brown.byron@epa.gov>; Gay Ludwick <gay@gdcillc.com> Subject: Re: Wolbachia doc Nancy, Sierra Club v. EPA 18cv3472 NDCA Tier 2 ED 002061 00043012-00001 Thanks so much for the responses. There remain serious concerns and I will send you a more substantive reply later today or by the weekend latest. We will be in DC next week on Tues and Wed and would be happy to sit down to discuss details if helpful. Please let me know. All my sincere regards Roy W. Bailey CEO Giuliani Deason Capital Interests, LLC Cell Ex. 6 Office i x7 6 1 L _______________________________________________ Rbailey@gdcillc.com Rbailev@baileystrategicadvisors.com On Jul 25, 2017, at 11:04 AM, Beck, Nancy <Beck.Nancy@epa.gov> wrote: Roy, Thank you for sending this information. In response to your comments, our staff checked on whether these concerns were addressed in the response to comments document that was issued August 30 2016. An overview of responses is below: Citations 1, 2, 3, 4, and 6: Addressed in EPA's response to comments Public Comment #3. eCxietamtipotna 5: This research is for (African armyworm), naoctommopslqetueiltyoedsi,ffaenrdenWt oorlgbaanchisima ,cSaupsoedsovpetreyra different responses depending on the host. This information, while interesting, cannot be used to make predictions about mosquitoes. Citation 7: Addressed in EPA's response to comments Public Comment #4. CCoitmatmioennst8#, 79., 10, and 11: Addressed in EPA's response to comments Public Citation 12: With respect to the Wolbachia phage encoding a toxin from the black wipmnhiodwadgoAuewllewbsBiepnridespterhrraea,isgnteheamirWscohcOsoeqmdug.imetAnoeeoendsmtewiesssearrfeeergfoneymroprttiiWnswtgouAtldboliaebCcdBh.itiaOsatt"rnioa)l.nyinImn1d2otoht(ehi"ssEahsuntakudvadepryaay, rotWahtisecOitWao-BisdsOopw-cBhiaaastpgpiehoWnagOe associated with it; however, phage are specific to their hosts, horizontal gene twrreaipdnoosrfwteerdsipsthidhaeatrpthtpoeexnWiinnOgse-oBqnupeehnvacoeglueitsiionenxwaprAryelbstsiBmedAeiensdcteahsleeas,Wegthoyelpbrtaeicpihsrionadoiunicnfeedctithciaeotntioo, nxaintnhdafirttotimhsenot black widow spider. Also, most importantly, viruses have been shown to incorporate host sequences numerous times, but this is the first report of a virus of an obligate intercellular parasitic bacterium having sequences from both hosts: bacterial and eukaryotic. The widow spider toxin is a huge multimeric toxin with Sierra Club v. EPA 18cv3472 NDCA Tier 2 ED 002061 00043012-00002 the entire 150kD monomer needing to be expressed and binding to form a tetramer to have full toxin activity. The sequence detected in the prophage sequence is only the C-terminus (maybe 18 kD) o f the entire monomeric protein (150 kD). This C-terminus has been implicated in passage through membranes to trhealetaWseotlhbeactohxiainaslownheeanreprboedinugcetdrainnstfhererespdidtoera. nFimurathlserwmhoerne,atfheemrealies no evidence mosquito bites and takes a blood meal from an animal. Citation 13, 14, and 15: The Wolbachiapipientis strains associated with River blindness and lymphatic filariasis are in different clades than the wAlbB, and the wAlbB strain is not associated with these diseases. If there are still concerns that you are worried are not adequately addressed, I'm sure we can get our scientific experts together for further discussions. Regards, Nancy Nancy B. Beck, Ph.D., DABT Deputy Assistant Administrator, OCSPP P: 202-564-1273 _____ Ex. 6_____ I beck.nancy@epa.gov From: Roy Bailey fmailto:rbailey@gdcillc.coml Sent: Sunday, July 16, 2017 1:39 PM To: Bennett, Tate <Bennett.Tate@epa.gov>; Brown, Byron <brown.byron@epa.gov>; Beck, Nancy <Beck.Nancy@epa.gov> Cc: Roy Bailey <rbailev@gdcillc.com>; Gay Ludwick <gav@gdcillc.com> Subject: Fwd: Wolbachia doc Tate, This additional info may be helpful as well. Thanks so much for your call and attention to the concerns. Best regards Roy W. Bailey CEO Giuliani Deason Capital Interests, LLC Cell! Ex. 6 ! Office Ex. 6 Rbailey@gdcillc.com Rbailey@baileystrategicadvisors.com Begin forwarded message: From: "Basta, Christopher" <CBasta@intrexon.com> Date: July 16, 2017 at 10:22:45 AM PDT To: Roy Bailey <rbailev@gdcillc.com> Sierra Club v. EPA 18cv3472 NDCA Tier 2 ED 002061 00043012-00003 Cc: "Kirk, Randal J" <RJ. Kirk@intrexon.com>, "Bobo, Jack" <JBobo@intrexon.com> Subject: Wolbachia doc Roy, RJ asked that I send you this document that provides a Wolbachia overview as well as a list of publications that cover various Wolbachia concerns & potential issues. Best, Chris Christopher Basta Vice President, investor Relations intrexon Corporation Work Ex. 6 Cell: Ex. 6 www.dna.com CONFIDENTIAL TRANSMISSION - To the extent this electronic communication or any of its attachments contain information that is not in the public domain, such information is considered by Intrexon Corporation to be confidential and proprietary. This communication is expected to be read and/or used only by the individual(s) for whom it is intended. If you have received this electronic communication in error, please reply to the sender advising of the error in transmission and delete the original message and any accompanying documents from your system immediately, without copying, reviewing or otherwise using them for any purpose. Thank you for your cooperation. <Wolbachia Overview and Publications Citing Concerns and Risks.docx> Sierra Club v. EPA 18cv3472 NDCA Tier 2 ED 002061 00043012-00004